In this study we established a new technique using a miniaturized

In this study we established a new technique using a miniaturized axial flow pump in sheep with chronically ischemic myocardium.

METHODS: Sheep (n = 15) underwent intracoronary sphere injection to create chronic ischemic heart

failure. Reduced EF was assessed using transesophageal echocardiography. All animals Geneticin Microbiology inhibitor underwent implantation of a new miniaturized axial flow pump via an extraperitoneal, subcostal surgical approach.

RESULTS: Our technique allows easy exposure of the diaphragmatic surface of the heart and. the descending aorta. Ten animals (range 65 to 78 kg) underwent off-pump implantation 30 (range 25 to 33) days after intracoronary sphere injection. All animals had significantly reduced EF (25 +/- 4.8%) and were receiving high doses of inotropic Blebbistatin agents to maintain cardiac function. Nine animals survived the surgical procedure. The average 12-hour blood loss was 435 ml. Cardiac index

improved significantly in all animals. The procedure time was not extended by any adverse events (60 to 145 minutes).

CONCLUSIONS: The extraperitoneal, subcostal surgical approach is less invasive than a median sternotomy and allows centrifugal or axial to be implanted quickly and without cardiopulmonary bypass (CPB). Avoiding CPB and an extensive mediastinal dissection can help to decrease significantly the number of complications in patients with end-stage organ failure. J Heart Lung Transplant 2011;30:834-7 (C) 2011 International Society for Heart and Lung Transplantation. All rights reserved.”
“Raman and emission properties of a nonpolar a-plane InGaN/GaN blue-green light emitting diode (LED) on an r-sapphire substrate are investigated and compared with a conventional c-plane blue-green LED. The output power of the a-plane LED was 1.4 mW at 20 mA. The c-plane LED has higher EQE, but it reaches the maximum at a lower forward current and the droop is faster than the a-plane counterpart.

As the reverse bias increased, GS-1101 purchase a blueshift in the PL spectra was not observed in the a-plane structure, which is indicative of an absence of quantum confined Stark effects. However, a strong blueshift in the electroluminescence spectra was still present, which means the In localization effects are relevant in nonpolar InGaN/GaN quantum wells. In the Raman spectra, a strong anisotropy of E-2(high) phonon modes was observed. By comparing the frequency of the E-2(high) modes, we demonstrate that the residual compressive strain in an a-plane LED is significantly smaller than in the polar counterpart. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3549160]“
“The processes of setting population reference intakes in the European Union and elsewhere have highlighted the paucity of data for informing the assessments and the need to take the opportunity to establish transparent, physiologically based approaches to setting reference values for safe and adequate intakes, including considerations of excess exposures.

Overall, 61% had poor outcome (death/any deficit) Concurrent neu

Overall, 61% had poor outcome (death/any deficit). Concurrent neurological comorbidity at diagnosis (odds ratio = 2.8; P = .029) predicted

poor outcome. Clinical trials are urgently needed to establish more effective treatment strategies.”
“Objective. The objective of this study was to investigate the effect of hydride ion on bone formation and bone-bonding strength at the early stage of implantation.

Study design. Implants and plates were treated in 2 ways: test implant (implant surface with hydride Selleckchem Staurosporine ion) and control implant (implant surface without hydride ion). Crystal structure of plate surfaces was analyzed by low angle x-ray diffractometry (XRD). Sixty implants (30 test implants and 30 control implants) were inserted into tibias of 10 rabbits. At 2 and 8 weeks postimplantation, tibias were retrieved and prepared

for removal torque tests (RTQ) and histomorphometric evaluation, respectively.

Results. TiH(2) diffractions appeared on the XRD pattern of the test surface whereas TiH2 did not CDK inhibitor drugs appear on the control surface. The test implants showed 51.28% and 64.63% greater RTQ values than did the control implants at 2 and 8 weeks (P = .010, .011, respectively). Histomorphometric evaluation demonstrated the test implants significantly increased bone-implant contact and peri-implant bone formation at 2 and 8 weeks.

Conclusion. These results suggest the presence of hydride ion in the implant surface may improve bone integration with implant surfaces at the early stage of implantation. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:e5-e12)”
“The distribution dynamics of a thin lubricant film on a bit-patterned media disk and its effect on the performance of the ultralow flying air bearing slider of disk

drives are studied by direct numerical simulations. Our analysis shows that the physics governing lubricant distribution dynamics changes when deep enough sub-100-nm nanostructures are patterned on the disk surface. JNK-IN-8 cost Air shearing under the slider that dominates lubricant flow on a flat disk may become negligible on a bit-patterned media disk. Surface tension and disjoining pressure become dominant factors instead. Our results show that disks with nanoscale patterns/roughness may no longer be treated as flat, and the air bearing load may strongly depend not only on the geometric detail of disk patterns but also on how lubricants are distributed on the patterns when slider-disk clearance is reduced to sub-10-nm. Air bearing load and consequently the slider’s flying attitude are affected by disk pattern geometry, average lubricant thickness, and material properties of lubricant such as the surface tension coefficient and Hamaker constant. The significantly expanded parameter space, upon which ultralow flying slider’s dynamics depends, has to be seriously considered in evaluating the head/disk interface tribology performance of next generation patterned media magnetic recording systems.

When dark-grown seedlings are

transferred to white light,

When dark-grown seedlings are

transferred to white light, the DNA content per plastid increases slightly during the first 4 h of illumination and then declines rapidly to a minimum at 24 h during the etioplast-to-chloroplast transition. Plastid autofluorescence (from chlorophyll) continues to increase as cpDNA declines, whereas plastid size remains constant. It is concluded that the increase in cpDNA that accompanies plastid enlargement is a consequence of cell and leaf growth, rather than illumination, whereas light stimulates photosynthetic capacity and cpDNA instability. When cpDNA from total tissue was monitored by blot hybridization and real-time quantitative PCR, no decline following transfer from dark to light was observed. The lack of agreement between DNA per plastid and cpDNA per cell may be attributed to nupts (nuclear sequences of plastid origin).”
“A total of buy Navitoclax 123 consecutive patients AZD0530 in vivo with advanced-stage, acute leukemia undergoing HSCT from HLA-identical sibling donors were analyzed. A G-CSF-primed DLI was planned within day 60 post-transplantation before hematologic relapse was diagnosed. Fifty of the 123 individuals received prophylactic DLI,

and 73 individuals received no prophylactic treatment. The incidence of grades IIIV acute graft-versus-host disease (GVHD) was 17% for patients receiving DLI and 23% for patients not receiving DLI (p = 0.35). The incidence of chronic GVHD was 38% for patients receiving DLI and 17% for patients not receiving DLI (p = 0.021). The two-yr cumulative incidence of relapse was significantly lower in patients who received prophylactic DLI (46%) compared with patients who did not receive prophylactic DLI (66%)

(p = 0.02). The three-yr probability of overall survival was higher in patients who received prophylactic DLI (36%) than in patients who did not receive Selleckchem INCB028050 prophylactic DLI (11%) (p = 0.001). The leukemia-free survival was also higher in patients who received prophylactic DLI (29%) than in patients who did not receive prophylactic DLI (9%) (p = 0.001). Our comparisons suggest that the prophylactic use of DLI can significantly increase survival of patients with advanced-stage, acute leukemia who receive HLA-identical sibling HSCT.”
“Organic field-effect transistors (OFET) based on both n-type (perylene derivative) and p-type (alpha-sexithiophene and pentacene) organic thin films are characterized using low-frequency noise spectroscopy to estimate the charge carrier mobility. The power spectral density shows that the exposure of OFET to air affects the thermal noise fluctuations and that the thermal noise RMS value depends on gate voltage. The power spectral density noise proves that the carrier mobility is gate-voltage dependent. Unlike the I-V measurements, the noise spectroscopy analysis demonstrates the dependence of the mobility on the carrier polarity.

3 mm), and lateral (21 8 +/- 5 7 mm) regions All pairwise compar

3 mm), and lateral (21.8 +/- 5.7 mm) regions. All pairwise comparisons of regional differences were statistically significant (P < 0.05), except for the comparison between the ventral and medial regions (P = 0.88). Evaluation of the CCT while controlling for age (2-5 years vs. 6-10 years) demonstrated an increased CTT with an increasing age for the central, ventral, medial and lateral regions. A decrease in the CTT of the dorsal region was noted with increasing age.

Conclusion

and Clinical Relevance Corneal touch threshold values in 40 eyes of 20 healthy adult alpacas were determined using a Cochet-Bonnet esthesiometer. This study demonstrated the central corneal region to be most sensitive. Values obtained may serve as reference values in subsequent studies.”
“A new nortriterpenoid saponin, 3,17-dihydroxy-28-nor-12-oleanen-16-one 3-O–d-galactopyranosyl (12)-CHEM1 selleck chemicals llc (1),

along with two pairs of known isomers, was isolated from the roots of Symplocos caudata Wall. Their structures were elucidated by spectroscopic and chemical methods.”
“OBJECTIVE: To determine the decision-making process of withholding and/or withdrawal (WH/WD) of life-sustaining treatment in cardiac intensive care units (ICUs) in Germany.

METHODS: A questionnaire regarding 16 medical and 6 ethical questions of WH/WD of life-sustaining treatment was distributed to the clinical director, senior ICU physician and head nurses of all German heart surgery centres (n=237 questionnaires). Furthermore, we present a literature survey using the key words ‘End-of-life care AND withholding/withdrawal of life support therapy AND intensive care unit’.

RESULTS: We received replies from 86 of 237

(36.3%) contacted persons. Concerning medical reasons, cranial computed tomography (CCT) with poor prognosis (91.9%), multi-organ failure (70.9%) and failure of assist AG-014699 supplier device therapy (69.8%) were the three most frequently cited medical reasons for WH/WD life-sustaining treatment. Overall, 32.6% of persons answered that ethical aspects influence their decision-making processes. Poor expected quality of life (48.8%), the patient’s willingness to limit medical care (40.7%) and the families’ choice (27.9%) were the top three reported ethical reasons. There was a significant difference regarding the perception of the three involved professional groups concerning the decision-making parameters: multi-organ failure (P = 0.018), failure of assist device therapy (P = 0.001), cardiac index (P = 0.009), poor expected quality of life (P = 0.009), the patient’s willingness to limit medical care (P = 0.002), intraoperative course (P = 0.054), opinion of family members (P = 0.032) and whether decision-making process are done collaboratively (clinical director, 45.7%; ICU physician, 52%; and head of nursing staff, 26.9%). Palliation medication in patients after WH/WD of life-support consisted of morphine (92%) and benzodiazepines (88%).

All patients underwent pre- and post-CRT 1 5-T rectal MR imaging

All patients underwent pre- and post-CRT 1.5-T rectal MR imaging and post-CRT DW MR imaging. For qualitative analysis, two radiologists who were blinded to pathologic staging and prior imaging data retrospectively and independently reviewed conventional MR images and the combined set of MR images and DW MR images over a 2-week interval and recorded their confidence level with respect to the CR to neoadjuvant CRT. Diagnostic accuracy was calculated

for each reviewer with receiver operating characteristic (ROC) curve analysis. For quantitative analysis, a third radiologist measured the apparent diffusion coefficient (ADC) of the region of interest three times. Mean ADCs in the CR group were compared AZD1208 with those in the non-CR group. Pathology reports served as the reference standard.

Results: Diagnostic accuracy (area under the ROC curve [Az]) in the evaluation of CR was significantly improved after additional review of DW MR images for both reviewers: For reviewer 1, Az improved from 0.676 to 0.876 (P = .005), whereas for reviewer 2, Az improved from 0.658 to 0.815 (P = .036). Mean ADC ([1.62 +/- 0.36] PF-2341066 x 10(-3) mm(2)/sec) (standard deviation) of the CR group (n = 11) was significantly higher than that

([1.04 +/- 0.24] x 10(-3) mm(2)/sec) of the non-CR group (n = 29) ( P < .0001).

Conclusion: Adding DW MR imaging to conventional MR imaging yields better diagnostic accuracy than use of conventional MR imaging alone in the evaluation of CR to neoadjuvant CRT in patients with locally advanced rectal cancer. (C) RSNA, 2009″
“The effect of hydrostatic pressure on the electrical behavior of quartz crystal resonators vibrating in the GW786034 megahertz range is investigated by impedance analysis. The responses in frequency and dissipation of five AT-cut polished quartz crystals

immersed in helium gas are analyzed and compared from conductance spectra around the resonance on several overtones. A model is then proposed to correlate the variations in frequency and dissipation with pressure and to explain the particular behavior observed on the fundamental harmonic mode. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3460805]“
“OBJECTIVES: To evaluate the cost-effectiveness of self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes treated with oral anti-diabetic agents (OADs) in Switzerland.

METHODS: A validated computer model of diabetes was used to project outcomes reported from a published longitudinal study of SMBG in type 2 diabetes patients, treated with OADs and with no history of SMBG, over a 30-year time horizon and cost-effectiveness was assessed from the perspective of a third party healthcare payer. Costs and clinical outcomes were discounted at 3% annually in line with recommended practice. Sensitivity analyses were performed.

A review of primary sources revealed at least seven different mod

A review of primary sources revealed at least seven different models of tympanostomy tube which were manufactured between 1845 and 1875. These included: Frank’s gold tube, Lincke’s rubber tube, Bonnafont’s silver cannula, Politzer’s hard rubber drain, Miot’s metallic eyelet, Voltolini’s gold ring, and Bonnafont’s eyelet. Study of these early innovations shows that all of the technical and surgical principles of the tympanostomy tube were known in the mid 19th century. Widespread introduction into otological practice

did not occur until the mid 20th century invention of the operating microscope. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Objectives: The aim of the study was to evaluate by quantitative magnetic resonance imaging the effect of celecoxib 200 mg daily on cartilage volume loss over 12 months in knee osteoarthritis.

Methods: The primary outcome of this study CFTRinh-172 IPI-145 clinical trial was to evaluate cartilage volume loss in the medial compartment of the knee (femoral condyle and tibial plateau) assessed by quantitative

magnetic resonance imaging on subjects receiving continuous treatment with celecoxib 200 mg daily for 12 months compared with a modelized historical control cohort, as expressed by the percentage loss from baseline. Safety of the medication was also assessed. Comparison of the observed volume loss to the expected loss was evaluated by a multivariate linear regression Quizartinib model based on a historical cohort.

Results: For the primary outcome, the 95% confidence intervals for the mean observed celecoxib cohort joint medial compartment

cartilage volume loss (6.81% [6.01; 7.60]) and mean predicted loss (modelized historical cohort) (5.65% [5.10; 6.19]) overlap, indicating no significant difference and hence no effect of celecoxib on the medial compartment cartilage volume loss. Similar findings were demonstrated for the lateral compartment cartilage loss. The safety data reported several minor adverse events similar to those typically seen in a 1-year clinical trial.

Conclusions: Although celecoxib was demonstrated to be safe for knee osteoarthritis at a 200 mg daily dose, it did not provide a protective effect on knee cartilage loss. Cohort modelization is an efficient and unbiased way to provide a comparator group for the assessment of novel treatments when classic head-to-head randomized controlled trials are not feasible. (C) 2010 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 40:185-192″
“Objectives: Recent studies have shown that allergic diseases may be associated with the pathogenesis of recurrent otitis media with effusion (OME). We aimed to assess the relationship between OME and allergic diseases and other types of disease in children with OME. We also evaluated the between group differences in the characteristics of middle ear effusion.


“Purpose of review

Two diseases


“Purpose of review

Two diseases SNX-5422 clinical trial associated with chronic kidney disease (CKD) have benefited from advances in the past year which are of great importance for rheumatologists: renal osteodystrophy, which is now clearly

associated with vascular calcification and cardiovascular death, and nephogenic systemic fibrosis, which appears presently as a new iatrogenic disorder, and therefore can be prevented.

Recent findings

Vascular calcification is a feature of renal osteodystrophy, which has received much recent attention. Hyperphosphatemia has been shown to play an important role by inducing a transcription factor, osterix, which promotes the transformation of vascular smooth muscle cells into osteoblats-like cells and matrix calcification. The effect of calcium load on vascular calcification is modulated by bone turnover. Calcium has been found to promote more vascular calcification in adynamic bone disease in which bone cannot act anymore as a buffer for absorbed calcium.

Summary

Management of renal osteodystrophy is progressing relentlessly, in particular, since the discovery of new phosphate binders, vitamin D derivates and calcium agonist. The need to maintain serum parathyroid hormone to levels higher than the normal range has been emphasized in CKD patients, who early develop skeletal resistance to the hormone. However, bone turnover has been found

excessively CP-868596 cost suppressed in dialysis patients whose serum parathyroid hormone levels met the recommended values, reflecting imperfections in the assays presently

used in clinical practice.

Nephrogenic systemic fibrosis has been linked to exposition of CKD patients to gadolinium-based contrast agents, by epidemiological and experimental data. Avoidance of gadolinium – in particular gadodiamide – enhanced MRI in CKD patients, now appears as an efficient way to prevent this very serious disease.”
“Purpose: To evaluate the safety and efficacy of spinal anesthesia compared with general anesthesia in patients who underwent percutaneous nephrolithotomy GW786034 nmr (PCNL).

Patients and Methods: One hundred patients with American Society of Anesthesiologists (ASA) score <3 were randomly divided into two groups according to the type of anesthesia. Spinal anesthesia was performed using an injection of 0.25 mg/kg bupivacaine 0.5% in the intrathecal space; no opium (fentanyl) agent was used. All procedures were performed with the patient in the prone position. Stone access was made by using fluoroscopic guidance, and the tract was dilated using a single-stage technique. All patients received a solution including 1 mg/kg morphine in every 100 mL physiologic saline through the volumetric pump during the 3-hour post-PCNL period in the recovery room. Afterward, morphine (0.05 mg/kg) was injected only according to the verbal rating scale greater than 3 after discharge from the recovery room until 24 hours after surgery.

CONCLUSIONS: The results obtained indicate that it is feasible to

CONCLUSIONS: The results obtained indicate that it is feasible to modify both physical and chemical properties of the carbon nanostructures Apoptosis Compound Library CNx and CST by HNO3 in such a way that they can be used to adsorb cations present in aqueous solutions. (c) 2008 Society of Chemical Industry”
“Hypothesis: Vinegar and aluminium acetate preparations are used for treatment of ear infections. It is

instrumental to know the minimal inhibitory concentration to get effective remedies. This study was performed to assess the lowest dilution of vinegar (specified content, 6% acetic acid) and aluminium acetate-tartrate solution (specified content, 1.4% aluminium and 6% acetic acid) to determine the minimum inhibitory concentration against bacteria commonly found in chronic ear infections.

Background: Laboratory study on 2 samples of aluminium acetate-tartrate and on 1 sample of natural white wine vinegar on antibacterial effects against Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Pseudomonas aeruginosa, and Escherichia coli.

Methods: Performing of a susceptibility testing-determination of the minimum inhibitory concentration (MIC) with the method of microbouillon dilution (DIN 58940 part 7).

Results: Acetic acid was found to be effective in DZNeP concentration vitro in concentrations of 0.1% to 0.2% against the tested

bacteria; aluminium acetate-tartrate solution was found to be effective in vitro in concentrations of 1.25% to 2.5% against the tested bacteria.

Conclusion: Vinegar respectively acetic acid diluted with water and aqueous aluminium acetate-tartrate solution could be effective ototopic preparations caused by one of the tested bacteria. For its effectiveness, an acid pH not higher than 4.5 is essential. Experiments Entinostat concentration with aluminium acetate-tartrate preparations on animals and clinical trials are required to obtain information about the response rates in ear infections and about any adverse effects.”
“Background: Analysis of left ventricular (LV) mechanical dyssynchrony

may provide incremental prognostic information regarding cardiac resynchronization therapy (CRT) response in addition to QRS width alone. Our objective was to quantify LV dyssynchrony using feature tracking post processing of routine cardiovascular magnetic resonance (CMR) cine acquisitions (FT-CMR) in comparison to speckle tracking echocardiography.

Methods: We studied 72 consecutive patients who had both steady-state free precession CMR and echocardiography. Mid-LV short axis CMR cines were analyzed using FT-CMR software and compared with echocardiographic speckle tracking radial dyssynchrony (time difference between the anteroseptal and posterior wall peak strain).

Results: Radial dyssynchrony analysis was possible by FT-CMR in all patients, and in 67 (93%) by echocardiography.

Together with terbinafine and fluconazole, itraconazole belongs t

Together with terbinafine and fluconazole, itraconazole belongs to the modern

highly effective systemic antifungal drugs DZNeP clinical trial with a favorable risk-benefit ratio and for this reason is a preferred therapy option for fungal infections of skin, nails and mucous membranes. Compared to terbinafine in the treatment of fingernail and toenail fungal infections, itraconazole offers the advantage of a broad antifungal spectrum and better effectiveness against onychomycosis caused by yeasts yet appears inferior with regard to the more common dermatophyte infections. Itraconazole constitutes an important therapy option, along with fluconazole, terbinafine, ketoconazole and griseofulvin, for the treatment of dermatophyte infections of glabrous skin (tinea pedis, tinea manuum, tinea corporis and tinea cruris) in adults following unsuccessful topical therapy. In the oral therapy of tinea capitis, itraconazole plays an especially important role, in particular for disease caused by Microsporum canis (for children, however, only off-label use is feasible currently). In the treatment of oropharyngeal candidiasis, candidiasis of the skin and vulvovaginal candidiasis, itraconazole and fluconazole are the

preferred treatment options in cases in which topical therapy has proven unsuccessful.”
“African PD98059 trypanosomiases, including the human disease referred to as ‘sleeping sickness’ and Dinaciclib ic50 the animal diseases such as nagana, surra and dourine, are neglected vector-borne diseases that after years of research still need improved diagnosis and chemotherapy. Advances in proteomics offer new tools to define biomarkers, whose expression may reflect host-parasite interactions

occurring during the infection. In this review, the authors first describe the current diagnostic tools used to detect a trypanosome infection during field surveys, and then discuss their interests, limits and further evolutions. The authors also report on the contribution of molecular diagnostics, and the recent advances and developments that make it suitable for fieldwork. The authors then explore the recent uses of proteomics technology to define host and parasite biomarkers that allow detection of the infection, the power and constraints of the technology. The authors conclude by discussing the urgent need to use the biomarkers discovered in order to develop tools to improve trypanosomiasis control in the near future.”
“Baccharis is an important genus of Asteraceae and it comprehends approximately 400 species, many of which are frequently used in folk medicine as analgesic, diuretic, spasmolytic, antidiabetic, antiseptic and stomachic. Baccharis singularis belongs to the Singularis group and is popularly known as cambara-de-praia and cambara-da-serra. It is a shrub which occurs in Brazil, from Bahia to Rio Grande do Sul.

Here, further studies were performed to examine whether this fini

Here, further studies were performed to examine whether this finishing would satisfy the requirements for commercial antimicrobial textile

production in terms of washing durability, its compatibility with dyeing and its effects on textile physical properties. The finishing was found to be very durable, sustaining at least 25 washing cycles without significant reduction in the antimicrobial activity. The process was compatible with reactive dyes, although other types of dyes (acid dyes, chrome dyes, and Premetalized dyes) all reduced PHMB uptake by similar to 50%. The finishing had little adverse effect on the tensile strength, handle or whiteness of the fabrics. This process therefore meets the requirements Acalabrutinib of and holds promise for the commercial production of antimicrobial wool textiles. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 2882-2887, 2010″
“One of the challenging problems in biology and medicine is exploring the underlying mechanisms of genetic diseases. Recent studies suggest that the relationship between genetic diseases and the aging process is important in understanding the molecular mechanisms of complex diseases. Although some intricate associations have been investigated for a long time, the studies are still in their early stages.

In this paper, we construct a human disease-aging Belnacasan research buy network to study the relationship among aging genes and genetic disease genes. Specifically, we integrate human protein-protein interactions (PPIs), disease-gene associations, aging-gene associations, and physiological system-based genetic disease classification information

in a single graph-theoretic framework and find that (1) human disease genes are much closer to aging genes than expected by chance; and (2) diseases can be categorized into two types according to their relationships with aging. Type I diseases have their genes significantly close to aging genes, while type II diseases do not. Furthermore, we examine the topological characters of the disease-aging network from a systems perspective. Theoretical results reveal that the genes of type I diseases are in a central position Transferase inhibitor of a PPI network while type II are not; (3) more importantly, we define an asymmetric closeness based on the PPI network to describe relationships between diseases, and find that aging genes make a significant contribution to associations among diseases, especially among type I diseases. In conclusion, the network-based study provides not only evidence for the intricate relationship between the aging process and genetic diseases, but also biological implications for prying into the nature of human diseases.”
“The objective of this study was to use mechanical and acoustic methods developed in our laboratory to monitor the changes in crispiness of a Crackerbread biscuit following equilibration at different water activities (a(w)). Crackerbread samples were equilibrated at a(w) of 0.113-0.98.