The NSHD recruited participants at birth in 1946 and has followed

The NSHD recruited participants at birth in 1946 and has followed them at regular intervals since then, whereas the MWS recruited women in middle age. For 541 women who were participants in both studies, we used statistical measures of association

and agreement to compare self-reported MWS data on body size throughout life and reproductive history, obtained in middle age, to NSHD data measured or reported close to the relevant ages. Likely attenuation of estimates of linear disease-exposure associations due to the combined effects of random and systematic errors was quantified using regression dilution ratios (RDRs).

Results: Data from the two studies were very strongly correlated for current height, weight and body mass index, and age at menopause (Pearson r = 0.91-0.95), strongly correlated Compound Library for birth weight, parental heights, current waist and hip circumferences and waist-to-height ratio (r = 0.67-0.80), and moderately correlated for age at menarche and waist-to-hip ratio (r = 0.52-0.57).

Self-reported categorical body size and clothes size data for various ages were moderately to strongly associated with anthropometry collected at the relevant times (Spearman correlations 0.51-0.79). Overall agreement between the studies was also good for most quantitative variables, although all exhibited both random and systematic Kinase Inhibitor Library purchase reporting error. RDRs ranged from 0.66 to 0.86 for most variables (slight to moderate attenuation), except weight and body mass index (1.02 and 1.04, respectively; little or no attenuation), and age at menarche, birth weight and waist-to-hip ratio (0.44, 0.59 and 0.50, respectively; substantial attenuation).

Conclusions: This study provides

some evidence that self-reported data on certain anthropometric and reproductive factors may be adequate for describing disease-exposure associations in large epidemiological studies, provided that the effects of reporting errors are quantified and the results are interpreted with caution.”
“Objective: Evaluation of 3 different kinds of buy KU-55933 autologous substitutes for simple myringoplasty.

Study Design: Retrospective review of myringoplasty cases.

Patients: A total of 117 patients (52 women with 52 ears and 65 men with 65 ears) with an average age of 25.6 years (range, 12-51 yr) were examined. Forty-two cases exhibited large perforations, and 75 exhibited small perforations.

Intervention: Myringoplasty with temporal fascia, tragus perichondrium, or tragus cartilage-perichondrium composite grafts were randomly used in this comparative study. All the 117 operations were performed by a single surgeon.

Main Outcome Measures: Otoscopic findings as assessed by a hearing examination using a quad-frequency pure-tone average air-bone gap.

Results: Recurrent defects were not observed in the small perforation group repaired with autologous substitutes. The graft acceptance rate in this group was 100%.

Primary outcome was treatment success of aztreonam monotherapy S

Primary outcome was treatment success of aztreonam monotherapy. Secondary analyses included need for modification to antimicrobial therapy, patients transitioned to aztreonam from another empiric regimen, and patients receiving aztreonam in combination with other antibacterial agents.

ResultsIn patients prescribed aztreonam for first fever, 11 of 27 (40.7%) patients who received aztreonam alone and 19 of 40 (47.5%) given

aztreonam plus another antibiotic responded within 96h (P=0.62). Twenty-four (89%) patients prescribed aztreonam monotherapy were alive when FN resolved or treatment ended. Infectious mortality was low (1 patient, 3.7%). In patients prescribed aztreonam monotherapy following an adverse reaction to cefepime, 6 of 11 (54.5%) responded within 96h of initiating aztreonam; 10 (91%) were alive when FN resolved or treatment ended.

ConclusionAztreonam monotherapy find more may be acceptable for use in patients with a history of beta-lactam hypersensitivity or following an adverse reaction with another beta-lactam. Further

studies are needed to compare efficacy of aztreonam monotherapy with other therapies for the treatment of FN.”
“SETTING: Two towns in Campo de Gibraltar, southern Spain, with a small foreign population and higher tuberculosis (TB) incidence and human immunodeficiency virus (HIV) prevalence than the national average.

OBJECTIVE: To determine the relationship between HIV-TB and P005091 Ubiquitin inhibitor non-HIV-TB incidence

and social deprivation and other potential individual and contextual determinants.

METHODS: In a cross-sectional longitudinal study, individual TB case variables were identified from three sources-routine surveillance, laboratory and hospital discharge records-from 1997 to 2007. Community variables were obtained at the census tract level. A deprivation index was calculated based on percentages of unemployment, low educational level and unskilled labour. Multilevel Poisson models were estimated for TB incidence rates for patients with and without HIV.

RESULTS: A total of 490 TB cases were included. Sex and age at individual level and deprivation and residence in the port area at census tract level were associated both with HIV-related TB and with non-HIV-TB. Household crowding contextual variables were also associated with HIV-related TB incidence. Full models account for 78.9% and 51.7% reductions in second-level variance.

CONCLUSION: Socio-economic deprivation is associated with higher rates of HIV-TB and non-HIV-TB. Diverse individual and contextual potential risk factors suggest different pathways of transmission. It is necessary to extend the framework for intervention beyond individual-based strategies to the socio-economic contexts in which people live.”
“We identified 22 cases of influenza infection among renal transplant recipients and matched them with 66 controls by influenza season to explore risk factors for influenza infection.

05, chi (2)) This systematic review confirms that OS-MRS stratif

05, chi (2)). This systematic review confirms that OS-MRS stratifies the mortality risk in the three-risk classification subgroups of patients. The OS-MRS can be used for pre-operative identification of high-risk patients undergoing primary Roux-en-Y gastric bypass surgery.”
“A 55-year-old man with scleroderma treated with prednisone and etanercept presented with enlarging sporotrichoid nodules on

the forearm. Microscopically, there were large circumscribed dermal and subcutaneous nodules of spindled and epithelioid cells, resembling a spindle cell neoplasm. Small foci of neutrophils were also present, and a subsequent Ziehl-Neelsen stain highlighted beaded acid-fast bacilli in the interstitium. Tissue culture demonstrated Mycobacterium

chelonae. Cutaneous mycobacterial spindle Blebbistatin datasheet cell pseudotumor is an exceedingly rare lesion, with only 6 previously reported cases. Although these included patients with autoimmune disease receiving immunosuppressive therapy, this is the first case reported in association with a tumor necrosis factor alpha inhibitor, etanercept. Furthermore, this represents the first mycobacterial spindle cell pseudotumor described in association with M. chelonae. Mycobacterial spindle cell pseudotumor should be considered in the differential diagnosis of cutaneous spindle cell proliferations, especially in immunocompromised patients.”
“A 72-year-old man with diabetes mellitus and hypertension was admitted to our hospital with lightheadedness. The patient showed lateropulsion to the right side, but his neurological findings were otherwise normal. Brain magnetic resonance AR-13324 cost images SB273005 showed a fresh ischemic infarct in the left dorsal

part of the lower pons. Body lateropulsion is characterized by an irresistible falling to one side and has been reported in lesions in several brain regions. However, it has rarely been reported in pontine lesions. We suggest that physicians should be aware that pontine lesions can cause isolated body lateropulsion without other neurological deficits.”
“OBJECTIVES: Glycogen synthase kinase-3 beta (GSK-3 beta)/beta-catenin signaling mediates osteogenesis in response to mechanical loading. We tested the hypothesis that local administration of a GSK-3 beta inhibitor could stimulate new bone formation in the expanding premaxillary suture.

Materials and methods: Thirty-five SpragueDawley rats were subjected to premaxillary suture expansion using a helix spring. The experimental rats were given one or two local injections of SB-415286, a small-molecule GSK-3 beta inhibitor. Animals were administered calcein and sacrificed on day 7 to quantify new bone formation. To evaluate the proliferation and differentiation of osteoblasts, rats were labeled with bromodeoxyuridine on day 1 and sacrificed on day 2 or 4. beta-catenin expression was evaluated by immunohistochemical staining.

The mean treatment efficacies for the right and left sides using

The mean treatment efficacies for the right and left sides using the FWCS were -1.85 +/- 0.82 and -1.70 +/- 0.71, respectively. Nine of 10 participants were satisfied with the procedure. Transient hyperpigmentation and slight exfoliation were observed in one patient after the last treatment, but this disappeared within 10 weeks.

CONCLUSION In eFT-508 treating

periorbital wrinkles, a 2,790-nm YSGG laser treatment might be an effective treatment modality with minimal complications.”
“Volatile organic compounds of Schenella pityophilus have been identified via solid-phase microextraction-gas chromatographymass spectrometry analysis. Ten compounds have been identified, in which 3-methylthio-1-propene was the most significant component. Some other components were previously identified

in Tuber aestivum and Tuber melanosporum.”
“BACKGROUND AND OBJECTIVE The water content of epidermis below the stratum corneum is more than 70%. The 2,940-nm wavelength is at the peak of water absorption, making it an ideal wavelength for ablation of skin. The purpose of this study was to determine the effectiveness and safety of a novel erbium-doped yttrium aluminum garnet (Er:YAG) laser with micron tips in the removal of cutaneous lesions.

METHODS GKT137831 datasheet Fourteen subjects with various cutaneous lesions received a single treatment with an Er:YAG laser, using an average fluence of 104.7 J/cm(2) (range 99-314 J/cm(2)), a mean repetition rate of 11.7 Hz, and straight and curved tips with a 400- to 600-mu m spot size. One subject received two treatments with a 1-month interval. The majority of subjects (80%, n = 12) did not require anesthesia.

RESULTS Clearance of 76% to 100% was obtained in 33% (n = 5) of subjects 1 month after treatment, 67% (n = 10) of subjects at 3 months, and 100% (n = 15) of subjects at 6 months. Investigators noted complete lesion clearance in all subjects 6 months after treatment. Ninety-three percent of subjects (n = 14)

reported satisfaction Selleckchem Duvelisib with the procedure and its outcome.

CONCLUSION The 2,940-nm wavelength combined with small micron spot size tips provides safe and effective clearance of cutaneous lesions, even in hard-to-reach locations.”
“Essential oil extracted from aerial parts of Artemisia nilagirica was analysed by gas chromatographymass spectroscopy. Forty-three constituents amounting to 98.16% of the total essential oil contents were identified. The essential oil contained approximately 79.91% monoterpenoids and 18.25% sesquiterpenoids. a-Thujone (36.35%), beta-thujone (9.37%), germacrene D (6.32%), 4-terpineol (6.31%), beta-caryophyllene (5.43%), camphene (5.47%) and borneol (4.12%) were identified as the major constituents. The essential oil exhibited significant antifungal activity against Rhizoctonia solani (ED50, 85.75?mg?L-1), Sclerotium rolfsii (ED50, 87.

In Europe both the amplitude and the magnitude of outbreaks of HF

In Europe both the amplitude and the magnitude of outbreaks of HFRS have increased. The mechanisms that drive the incidences are complex and multi-factorial and only partially due to increased awareness and improved diagnostic tools. Risk determinants include reservoir ecology, virus ecology and anthropogenic factors. The dogma of one specific rodent species as primordial reservoir for a specific hantavirus is increasingly challenged. New hantaviruses have been discovered in shrews, moles and bats and

increasing evidence points at host-switching events and co-circulation in multiple, sympatric reservoir species, challenging Selleck Vorinostat the strict rodent-virus co-evolution theory. Changing landscape attributes and climatic parameters determine fluctuations in hantavirus epidemiology, for instance through increased food availability,

prolonged virus survival and decreased biodiversity.”
“OBJECTIVE: To determine the utility of pulse pressure variation (Delta RESPPP) in predicting fluid responsiveness Bcl-xL protein in patients ventilated with low tidal volumes (V-T) and to investigate whether a lower Delta RESPPP cut-off value should be used when patients are ventilated with low tidal volumes.

METHOD: This cross-sectional observational study included 37 critically ill patients with acute circulatory failure who required fluid challenge. The patients were sedated and mechanically ventilated with a

V-T of 6-7 ml/kg ideal body weight, which was monitored with a pulmonary artery catheter and an arterial line. The mechanical ventilation and hemodynamic parameters, including Delta RESPPP, were measured before and after fluid challenge with 1,000 ml crystalloids or 500 ml colloids. Fluid responsiveness was defined as an increase in the cardiac index of at least 15%. NCT01569308.

RESULTS: A total of 17 patients were classified as responders. Analysis of the area under the ROC curve (AUC) showed that the optimal cut-off point for Delta RESPPP to predict fluid responsiveness was 10% (AUC = 0.74). Adjustment of the Delta RESPPP to account for driving pressure did not improve the accuracy (AUC = 0.76). A Delta RESPPP >= 10% was a better predictor of fluid TGF-beta inhibitor responsiveness than central venous pressure (AUC = 0.57) or pulmonary wedge pressure (AUC = 051). Of the 37 patients, 25 were in septic shock. The AUC for Delta RESPPP >= 10% to predict responsiveness in patients with septic shock was 0.84 (sensitivity, 78%; specificity, 93%).

CONCLUSION: The parameter Delta RESPPP has limited value in predicting fluid responsiveness in patients who are ventilated with low tidal volumes, but a Delta RESPPP. 10% is a significant improvement over static parameters. A Delta RESPPP >= 10% may be particularly useful for identifying responders in patients with septic shock.

The emulsion particle structure was investigated by TEM and parti

The emulsion particle structure was investigated by TEM and particle size analyzer. The results indicate that the average emulsion particle diameter is about

130 nm and the particles grow without secondary nucleation. Samples 1 and 2 prepared with 0.7 and 0.5 phm (per hundred gram monomer) CTA respectively, show high peel strength but poor heat resistance property. On the contrary, the sample 3 prepared with 0.1-phm CTA exhibits low peel strength but relatively good heat resistance. However, sample 4, which was synthesized with 0.5-phm CTA and 0.4-phm acetoacetoxy ethyl methacrylate (AAEM) in core but 0.5-phm CTA and 0.6-phm AAEM in shell stages, shows high peel strength (1032.9g/in.) AS1842856 in vitro and good heat resistance property (524.9 g/in.). In addition, sample 5 also demonstrates high peel strength (987.2

g/in.) and good heat resistance property (643.5 g/in.) when it was synthesized using 0.1-phm CTA but no AAEM in core, 0.36-phm CTA and 0.75-phm AAEM in shell stages. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 2857-2865, 2011″
“Current Centers for Disease Control and Prevention (CDC) recommendations MLN2238 clinical trial suggest all pregnant women have human immunodeficiency virus (HIV) antibody testing early in pregnancy. For women with specific identified risks for HIV-1 infection, the CDC recommends repeat testing in the third trimester. We report 3 cases of infants perinatally infected with HIV-1 whose mothers tested negative BEZ235 chemical structure for HIV-1 during the first trimester of pregnancy. Because they were not considered to be “”high risk”" for HIV-1 infection, they did not

have a third trimester HIV test. These cases suggest that repeat HIV antibody testing may be necessary to avoid cases of perinatal transmission that might be prevented with antiretroviral treatment during pregnancy.”
“Factor V Leiden (FVL) is the most common monogenic disorder that causes activated protein C (APC) resistance, creating hyper-coagulation. The mutation shows an uneven geographic distribution, significantly high in European populations. The mutation is believed to have originated approximately 20 000 years ago probably from a geographic region close to Anatolia. This fact makes it noteworthy to search for the mutation in ancient populations that once lived in this area. One of these civilizations, Urartu was centered around Van Lake in Eastern Turkey. The archeological remains from the excavations of the region are dated back to 1000 BC. Teeth, taken from the excavations of Van Yoncatepe fortress, were taken into DNA analysis considering all the precautions for ancient DNA analysis. Multiplex STR (Short Tandem Repeats) analysis were performed both to determine the gender of the samples and to conclude that the samples are preserved from modern DNA contamination.

The greatest reducing power was observed in PV relative to the ot

The greatest reducing power was observed in PV relative to the other vinegars. The ferric reducing ability of plasma (FRAP) of PV, PMV, GV, and BV were 1.012, 0.969, 0.931, and 0.856 at a dose of 1 mL, respectively. Therefore, our study verified that the GV, PV, and PMV have powerful antioxidant activities which are correlated with its high level of phenolics, particularly Fedratinib purchase gallic,

acid, and epigallocatechin.”
“The aim of the study was to identify and quantify the reasons for the high bladder cancer rates in Turkey. We conducted a case-control study in Manisa, Turkey, in 2011. The study included 173 patients with incident, histologically confirmed bladder cancer and 282 controls who were frequency matched by age, sex and geographic area, admitted to the main hospital of Manisa for a wide range of acute diseases. Adjusted odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were derived from multiple logistic regression models. Compared with never smokers, the OR was 2.9 (95% CI 1.5-5.4) for moderate (<20 cigarettes/day) and 4.0 (95% CI 1.7-9.6)

for heavy smokers. The association was stronger for unfiltered black tobacco (OR=5.4) and for longer duration of smoking (40 years, OR=5.3). There was a strong inverse correlation with social class indicators, with ORs of 0.2 (95% CI 0.1-0.4) for more-educated compared with less-educated individuals. There was no significant association with a group of five occupations a priori defined as being of CDK assay high risk (OR=1.3), nor with farming (OR=1.2). Bladder cancer risk was directly related to the history of urinary tract infections (OR=1.9,

95% CI 1.2-3.1) but not to diabetes (OR=0.7) or kidney (OR=0.7) and prostate (OR=1.3) diseases. Tobacco is the major risk factor for bladder cancer in Manisa, being responsible for 56% of cases; check details urinary tract infections account for 19% of cases, whereas the role of occupational exposure is limited in this, predominantly rural, population.”
“Two new compounds named fischeacid (1) and fischexanthone (2), together with eight known compounds, were obtained from the culture of a marine-derived fungus Neosartorya fischeri strain 1008F(1). The structures of the new compounds were elucidated based on the spectroscopic data. Bioassays indicated that AGI-B4 (5) and 3,4-dihydroxybenzoic acid (10) showed potent inhibitory effect on the replication of tobacco mosaic virus, and AGI-B4 also possessed an inhibition of the cell proliferation of human gastric cancer cell line SGC-7901 and hepatic cancer cells BEL-7404.”
“Danshen (Salvia miltiorrhiza Bunge) is a traditional Korean medicine that is commonly used for the treatment of inflammatory diseases such as edema, arthritis, hepatitis, and endangitis.

The Method is Used to obtain the hysteresis loops and study the s

The Method is Used to obtain the hysteresis loops and study the switching

behavior of [Co/Pd] multilayers coupled to different seed layers. Results show that Cu seed layer helps to reduce the switching field distribution (SFD) and increase the coercivity while Co underlayer with an in-plane anisotropy helps to reduce the coercivity and increase the SFD. Furthermore, the magnetization in the Co in-plane layer is Found to be pointing out of plane possibly due JNJ-26481585 nmr to exchange coupling with the [Co/Pd] multilayers. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3240346]“
“Objectives A diagnosis of cancer in childhood places a considerable economic burden on families, although costs are not well described. The objectives of this study were to identify and determine independent predictors of

the direct and time costs incurred by such families. Methods A prospective, cost-of-illness study was conducted in families of children newly diagnosed with cancer. Parents recorded the resources consumed and costs incurred during 1?week per month for three consecutive months beginning the fourth week following diagnosis and listed any additional costs incurred ISRIB purchase since then. Descriptive and multiple regression analyses were performed to describe families’ costs (expressed in 2007 Canadian dollars) and to determine direct and time cost predictors. Results In total, 28 fathers and 71 mothers participated. The median total direct and time costs in 3?months were $CAD3503 and $CAD23?130, respectively, per family. The largest component of direct costs was travel and of time costs was time allocated previously for unpaid activities. There were no statistically significant predictors of direct costs. Six per cent of the variance for time costs was explained by language GSK J4 spoken at home. Conclusions Families of children with cancer are confronted with a wide range of direct and time costs, the largest being travel and time allocated previously for unpaid activities. Copyright (c) 2011 John Wiley & Sons, Ltd.”
“The objective of this study was to measure the correlation of

maximum urethral closure pressure (MUCP) with Valsalva leak point pressure (VLPP) in women with urodynamic stress incontinence using air-charged urodynamic catheters.

Records of all women who underwent urodynamic testing for urinary incontinence using air-charged catheters over a 3-year period were reviewed. Data included scores on the Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7).

One hundred ninety-three women met the criteria for urodynamic stress incontinence. There was a modest correlation of MUCP with VLPP at 200 mL (r = 0.46, p < 0.001) and a low correlation of MUCP with VLPP at maximum capacity (r = 0.35, p < 0.001). There was no correlation of UDI-6 or IIQ-7 scores with MUCP or VLPP.

We compared the respondents’ management against evidence-based pr

We compared the respondents’ management against evidence-based practice.

The survey took the form of a questionnaire, which was sent to members of The Association of Paediatric Anaesthetists (APAGBI) and to Royal College tutors. The questionnaire was sent in paper format to the College Tutors and in digital format to APAGBI members. Emphasis was placed upon preoperative preparation, induction

technique, airway management, analgesia, postoperative nausea and vomiting strategy, fluid management and emergence from anesthesia.

Responses were obtained from 173 individuals representing a broad cross-section of anesthetists from teaching and district general hospitals. Findings are as follows: the application of topical anesthetic cream is commonplace (93%), with Ametop((R)) being the primary preparation used; the intravenous route was preferred to induce LDN-193189 anesthesia; most practitioners intubate the trachea to maintain the airway during anesthesia

(79%); a muscle relaxant was employed to assist intubation of the trachea in 47% of respondents and the routine use of suxamethonium was reported to be uncommon (9%); the administration of prophylactic ondansetron and dexamethasone was reported by 79% and 70% of respondents respectively; and nonsteroidal anti-inflammatory drugs (NSAIDs) are used by 77% of individuals either pre-emptively or during SB203580 the intraoperative period.

Whilst there is individual variability in the management of these cases, the majority of anesthetists prefer the intravenous route for induction of anesthesia, after application of topical anesthetic cream. It is routine practice to intubate the trachea, administer paracetamol, NSAIDs, strong opiates and antiemetics.”
“Commercially used per- and polyfluorinated compounds (PFCs) have been widely detected in humans, but the sources of human exposure are not fully characterized.

The objectives of this study were to assess the relative importance of different exposure pathways of PFCs in a group of Norwegians and compare estimated intakes with internal doses obtained through biomonitoring. Individual PFC intakes from multiple exposure sources for a study group of 41 Norwegian women were estimated using measured NSC23766 solubility dmso PFC concentrations in indoor air and house dust as well as information from food frequency questionnaires and PFC concentrations in Norwegian food. Food was generally the major exposure source, representing 67-84% of the median total intake for PFOA and 88-99% for PFOS using different dust ingestion rates and biotransformation factors of ‘precursor’ compounds. However, on an individual basis, the indoor environment accounted for up to around 50% of the total intake for several women. Significant positive associations between concentrations of PFCs in house dust and the corresponding serum concentrations underline the importance of indoor environment as an exposure pathway for PFCs.

In both cases, carotenes were far less degraded than synthetic be

In both cases, carotenes were far less degraded than synthetic beta-carotene. However, the degradation of lycopene was still rapid (around 1 mM lycopene degraded per hour), see more whereas beta-carotene was almost not bleached. Moreover, in gac, the cleavage of the beta-carotene’s

molecule was situated nearer the extremity of the cycle than for pure beta-carotene. It gave rise essentially to beta-cyclocitral. For encapsulated beta-carotene, the presence of PLA modified this site to the C9-10 bond which is the favoured cleavage site of pure beta-carotene.

We conclude that the presence of lycopene in gac has a protective role on the molecule of beta-carotene and modifies the cleavage site. However, the supramolecular structure is still very important in the orientation of cleavage

as the encapsulation in PLA particles increases degradation and modifies the cleavage site. (C) 2011 Elsevier Ltd. All rights reserved.”
“To compare laparoscopic-assisted vaginal hysterectomy (LAVH) with and without bipolar vessel sealing (BVS) using the LigaSure (TM) device by meanings of intra- and postoperative course.

In a retrospective case-control study 362 female patients (mean age 54.3 +/- A 9.5 years) were included check details who underwent LAVH with (n = 252) and without (n = 110) use of BVS. Intra- and postoperative courses and adverse events were evaluated.

A shorter mean operating time was found for LAVH with the use of BVS (65.28 +/- A

16.33 min) when compared with LAVH without the use of BVS (83.73 +/- A 21.53 min, P < 0.005). The mean postoperative stay did not differ significantly between the two groups (P > 0.05); 15 out of 251 (6.0%) patients were found to have adverse events during or after LAVH with the use of BVS in contrast to 16 out of 110 (14.5%) patients during or after LAVH without the use of BVS (P < 0.05). Following the MLN2238 use of BVS significantly less patients reported postoperative pain for more than 7 days after the operation in contrast to the use of sutures (0/251 [0%] vs. 3/110 [2.7%], respectively, P < 0.05).

The use of LigaSure (TM) is effective in decreasing operating time, the overall complication rate and postoperative pain.”
“Thyroid hormones affect the function of almost every body organ, and thyroid dysfunction produces a wide range of metabolic disturbances. Severe hypothyroidism is associated with significant effects on the kidney. The pathophysiology is thought to be multifactorial, while the exact mechanism remains unclear. Hypothyroidism as a cause of renal impairment is usually overlooked, leading to unnecessary diagnostic procedures. We describe two patients with acute renal failure due to severe hypothyroidism in whom thyroid hormone substitution therapy led to a significant improvement in renal function.