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Micron 2006, 37:544–550.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions DEM participated in the design, data acquisition, manuscript writing, carried out statistical analyses and have given final approval of the version to be published. PTB participated in study design and revised manuscript. CYP performed data analysis and helped to draft the manuscript. LEN check details supervised the design of the experiments and analyzed and interpreted of data. All authors approved the final manuscript.”
“Background Basic fibroblast growth DNA ligase factor (bFGF) is a heparin-binding growth factor that is secreted as a pleiotropic protein and can act on various cell types, including tumor cells. bFGF is hypothesized to have a critical role in the development of the nervous system , and for gliomas, the level of bFGF present has been shown to correlate with tumor grade and clinical outcome , bFGF has also been shown to be up-regulated in transformed glial cells and to be overexpressed in malignant gliomas . bFGF exerts its cellular functions through the binding of four FGF receptors (FGFRs), all of which are receptor tyrosine kinases (RTKs). The binding of bFGF by FGFRs recruits and activates several signaling pathways . Accordingly, down-regulation of bFGF using antibodies or antisense sequences has been shown to inhibit tumor cell tumorigenicity and metastasis [3, 5, 6].