We evaluated the changes and predictors of LSM value during antiviral treatment (AVT) using nucleos(t)ide analogues (NUCs) in patients with CHB. Methods: A total MG-132 clinical trial of 49 CHB patients [age (years): 46.9 ± 9.4,

male: 32 (65.3%)] who received AVT with NUCs and had serial LSM measurements were analyzed. Complete virological response (CVR) was defined when hepatitis B virus DNA level was below 60 IU/ml. Results: Patients were followed-up for a median of 21.7 months (range: 12 to 55 months). LSM value had significantly decreased after AVT with NUCs [median (quartile): 8.0 (5.1 – 12.8) to 6.3 (4.3 LY2109761 – 8.5), p < 0.001]. In subgroup analysis, LSM value decreased regardless of gender, age, body mass index, hepatitis b e angtigen status, follow-up duration, alanine aminotransferase level at baseline. However, LSM value significantly decreased

only in patients with CVR [median (quartile): 8.9 (6.1 – 16.7) to 6.3 (4.5 – 8.8), p < 0.001), but not in patients without CVR [median (quartile): 6.8 (4.5 – 9.1) to 6.0 (4.1 – 7.3), p = 0.23]. Changes in platelet count had an independent negative correlation with changes in LSM value (r = -0.54, p < 0.001). Conclusion: A significant decrease in LSM value was observed in CHB patients after AVT with NUCs, but not for patients who had not acheive CVR. Achieving CVR might be a key to decrease LSM value during AVT with NUCs. Key Word(s): 1. Chronic hepatitis B; 2. Liver stiffness; Isotretinoin 3. Longitudinal

change; 4. virological response; Presenting Author: DEEPAK SINGH Additional Authors: VINEET GUPTA, SUDEEP KHANNA, RAKESH TANDON Corresponding Author: DEEPAK SINGH Affiliations: DNB BOARD Objective: The microbiological profile of spontaneous bacterial peritonitis (SBP) in Indian patients with cirrhosis of the liver (CL) with ascites is limited.To study the prevalence of SBP and its microbiological profile in CL patients with ascites. Methods: One hundred consecutive patients with CL and ascites underwent diagnostic paracentesis.SBP was diagnosed when ascitic fluid culture was positive and polymorphonuclear leukocytes (PMN) were >250/mm3. Two variants were: culture negative neutrocytic ascites (CNNA) when ascitic fluid PMN count was >250 cells/ mm3 but culture was negative, and monomicrobial nonneutrocytic bacterascites (MNB) when a single organism was grown but PMN count was <250 cells/ mm3.. Bed side inoculation of ascitic fluid in blood culture bottle was done for organism isolation and culture sensitivity.