Thirty-three patients and their 20 physicians (18 cardiologists toward and 2 general practitioners) were enrolled; 23 patients (70%) fully completed the

study follow-up; 1 patient died (3%) and 5 (15%) withdrew. Four patients (12%) were lost to follow-up after they had received >80% of their intervention visits. There were no clinically or statistically significant differences in the baseline characteristics of patients who completed the study versus those who did not. Figure 1 Flow sheet from screening to study completion. Table 1 summarises the baseline characteristics of all the 33 patients who were enrolled. Table 2 summarises the outcome data for physicians and patients at study completion. Physician adherence with respect to any given drug class could only be evaluated in patients with an indication for that medication at baseline and at 5 months. As a result, of the 20 physicians who were enrolled, only 13

were evaluable for ACE-I/ARBs, 10 for β-blockers, and 11 for aldosterone antagonists. At baseline, 69% and 100% of physicians were appropriately prescribing ACE-I/ARB and β-blockers, respectively, over all of their patients enrolled in the study. At 5 months, this adherence rate increased to 77% of enrolled physicians for ACE-I/ARBs and decreased to 90% for β-blockers. For aldosterone antagonists, physician adherence was 17% at baseline and dropped to 0% at 5 months. These changes in physician adherence rates were not statistically significant. Table 1 Baseline characteristics of enrolled patients Table 2 Physician and patient adherence at baseline and 5 months For the 23 patients who completed the study, self-reported sodium intake declined by 1192 mg (p<0.01) from baseline. Their pill cap adherence decreased as only 4 of 23 (17%) patients were adherent at study completion

versus 10 of 23 (43%) at baseline (p=0.02). However, the proportion of patients scoring the maximum on MMAS improved from 9 (39.1%) at baseline to 15 (65.2%) at study completion (p=0.18). The feasibility of the protocol for patients was assessed as adherence to patient interventions: all patients received at least AV-951 1 intervention visit, 87% (29/33) of patients completed at least 4 (80%) of the protocol-required 5 scheduled intervention visits within the first month and 82% (27/33) of participants completed at least 9 (81.8%) of the protocol-required 11 intervention visits within the 4-month intervention period. Among all completed visits, 66% were performed in person and the remaining by phone. Given the small sample size, it is difficult to comment on the differences in outcomes based on whether a patient received the majority of interventions in person versus over the phone. All physicians received the study-supplied patient summary report within 2 weeks of the data being collected from the patient. The 33 patients reported a total of 20 hospitalisations during the study follow-up, for which medical records were reviewed.