These findings suggest that lycopene may have some influence on feeding and water-drinking behaviors. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Purpose: Glutamine (Gin) has protective, anti-inflammatory effects in animal models and humans. Antioxidant nutrients may exert synergistic effects on intestinal functions. Therefore, these combined nutrients may have a therapeutic potential during intestinal inflammation. This study was designed to investigate in humans the effects of a supplement composed of Gin and high-dosed antioxidant micronutrients

compared to isomolar Gin only, on duodenal R428 cost proteome.

Experimental design: Enteral perfusion of Gin (0.8 mmol.kg(-1).h(-1)) or supplement was performed in two groups of six healthy volunteers during 5 h before taking endoscopic duodenal biopsies. Protein expression was analyzed by 2-DE and the relevant proteins identified by MS/MS.

Results: About 1500 protein spots were revealed in both supplement and Gin conditions. Comparative proteomics analysis indicated that 11 proteins were differentially and significantly (p <= 0.05) expressed in response to the supplement. These proteins were essentially implicated in metabolism pathways, e.g. fatty acid binding protein-1 and 40S ribosomal protein

SA expressions were downregulated while manganese superoxide dismutase and retinal dehydrogenase-1 expressions Tariquidar mouse were upregulated.

Conclusions and clinical relevance: This study provides new information on human duodenal proteome and its nutritional modulation, and supports further clinical investigations designed to evaluate the effects of Gin plus antioxidants during intestinal inflammation

and cancer.”
“To investigate the acute effects of whole-body cryotherapy (WBC) on postural control, we measured postural sway (COP) in a quiet stance with eyes open in four consecutive 20-second tests: before and 1, 6 and 11 min after the WBC. Twenty-four healthy young subjects mafosfamide aged 19.3 +/- 0.9 were exposed to WBC (-110 degrees C) for 2 min. The time series recorded with a sampling rate of 100 Hz was used to evaluate postural performance (COP variability) and strategies (COP frequency and entropy). There were no differences between the pre- and post-WBC values of these measurements in the frontal plane; however, in the sagittal plane postural sway increased immediately after WBC (p < 0.05) and remained elevated throughout the experiment. Deteriorated performance brought about lagged changes in postural strategies, including a decrease in frequency and entropy. These changes remained sustained until the end of the experiment. In conclusion, the WBC caused a drop in complexity, adaptability, and automaticity in postural control, which accounted for specific constraints imposed on the postural system due to cooling. (C) 2013 Elsevier Ireland Ltd. All rights reserved.