The undergraduate medical course presented no difficulty to him, and until his graduation in 1966 he made quite a name as a sportsman, gaining a Full Blue for both cricket and baseball. In the latter, he was a success as a big hitting left hander and outfielder, but in cricket, by any criteria he was regarded as a player with a future as a fast bowler, who could have gone a long way in the sport, but he cut that short when he stopped playing at the age of 22 when he graduated in Medicine. It is worth recording here that fast bowlers in that game are generally noted for their attacking style and aggression. Greg’s cricket teammates recall a typical fast

bowler, but surprisingly, when inevitably on occasions he caused physical damage, he would http://www.selleckchem.com/products/epacadostat-incb024360.html be inclined Akt inhibitor to “ease up” – they blamed his adherence to his medical vocation. He married Helen Bath immediately after graduating and left for Hobart for Residency training, then for the U.S. At the Royal Hobart Hospital, Greg completed a research thesis with Professor Albert Baikie on the pathogenesis of multiple myeloma. He could not have predicted what a

great contribution he would make some years later to understanding of that blood disease that so profoundly affects the skeleton. Career advice was not so readily available in those days, so Greg made his own plans, arranging a position at the University of Rochester, New York USA, with the late Louis Lasagna, and he and Helen and their young children left for there in 1972. Looking

around for a suitable project, Greg came to the Raisz laboratory where there was great excitement about local non-hormonal factors over affecting bone resorption. One of these was produced by activated white cells and had been named Osteoclast Activating Factor when it was identified at the National Institutes of Dental Research in 1972. At this point, Greg realized that such a factor could be involved in the intense bone resorption that occurs in myeloma. He demonstrated that cultures of myeloma cells could produce such a factor. This had the spectacular outcome for someone so early in his first Fellowship, of two manuscripts published in the New England Journal of Medicine during his fellowship years and leading to an expanding program of research on how cancer could affect the skeleton. Ultimately, Greg and others identified a number of different cytokines that contributed to OAF activity. In 1974, Raisz was asked to head a new Division of Endocrinology at the University of Connecticut, and Greg moved with him, confident of success though neither had endocrine training. Joining with Gideon Rodan and other boneheads, he not only helped establish the division, but also a highly effective program in bone research and metabolic bone disease. In 1980, Greg moved on to be Head of the Division of Endocrinology and Metabolism at the University of Texas Health Science Center at San Antonio.