The reduction in background risk of cervical cancer by elimination of the most important HPV types will affect cost-effectiveness of screening programmes and may, in the long term, allow increasing screening intervals. Co-ordinated quality assurance/monitoring of HPV vaccination and cervical screening is advisable for finding the most efficient strategies for cervical cancer control. Data on vaccination coverage will be essential for every country performing HPV vaccinations. HPV vaccination registries are

preferable, but sales statistics and serosurveys may be alternatives. For rapid assessment of vaccine programme efficacy, the continuous monitoring of which HPV types are spreading in the population Copanlisib chemical structure will become necessary for early monitoring of ‘type replacement’ phenomena, inappropriate vaccination strategies or other reasons for vaccination failure. Surveys in sexually this website active teenagers and/or in younger participants of cervical screening programmes should be contemplated. As HPV-associated cancers and condylomas are now vaccine-preventable diseases from now onwards they should be subject to similar surveillance strategies as other vaccine-preventable diseases.

The recent WHO recommendation on HPV vaccination (http://www.who.int/wer/2009/wer8415.pdf and http://www.who.int/immunization/documents/positionpapers/en/index.html#hpv) includes information that will help countries make decisions about how HPV vaccination fits into their strategy for cervical cancer control. The authors alone are responsible for the views expressed in this publication and they do clonidine not necessarily represent the decisions, policy or views of the World Health Organization or the funding agencies. The findings and conclusions in this report are those of the authors. “
“The use of biological agents combined with methotrexate (MTX) in rheumatoid arthritis (RA) patients has strongly improved disease outcome. In this study, the effects

of abatacept on the size and function of circulating B and T cells in RA patients not responding to anti-tumour necrosis factor (TNF)-α have been analysed, with the aim of identifying immunological parameters helpful to choosing suitable tailored therapies. We analysed the frequency of peripheral B and T cell subsets, B cell function and T regulatory cell (Treg) inhibitory function in 20 moderate/severe RA patients, according to the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) criteria, primary non-responders to one TNF-α blocking agent, who received abatacept + MTX. Patients were studied before and 6 months after therapy. We found that abatacept therapy significantly reduced disease activity score on 44 joints (DAS)/erythrocyte sedimentation rate (ESR) values without causing severe side effects.