Science 324:268–272PubMedCrossRef Zerges W, Hauser C (2009) Protein mTOR inhibitor synthesis in the chloroplast. In: Stern D, Witman GB, Harris EH (eds) The Chlamydomonas sourcebook, vol 2. Elsevier, Amsterdam, pp 967–1026 Zhao T, Wang W, Bai X, Qi Y (2009) Gene silencing by artificial microRNAs in Chlamydomonas. Plant J 58:157–164CrossRef Zhu J, Fu X, Koo YD, Zhu JK, Jenney FE Jr, Adams MW et al (2007) An enhancer mutant of Arabidopsis salt overly sensitive 3 mediates both ion homeostasis and the oxidative stress response. Mol Cell Biol 27:5214–5224PubMedCrossRef Zimmer SL, Schein A, Zipor G, Stern DB, Schuster G (2009) Polyadenylation in Arabidopsis and Chlamydomonas organelles: the

input of nucleotidyltransferases, poly(A) polymerases and polynucleotide phosphorylase. Plant J 59:88–99PubMedCrossRef Enzalutamide Zybailov B, Rutschow H, Friso G, see more Rudella A, Emanuelsson O, Sun Q, van Wijk KJ (2008) Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. PLoS One 3:21994CrossRef”
“Beginning

in 1952 and extending well into 1954, Melvin Calvin pursued an apparently brilliant idea that involved a chlorophyll-sensitized photochemical reaction of thioctic (lipoic) acid with water to yield a reducing “–SH” and an oxidizing “–SOH” group which could conceivably provide the reduced pyridine nucleotides and the hydroperoxides leading to oxygen in photosynthesis (see e.g., Barltrop et al. 1954; Calvin 1954). (For Calvin’s biography, see Seaborg and Benson (1998).) Everyone in the laboratory was impressed and excited. In the first public presentation of the theory (American Association of the Advancement of Science (AAAS) Meeting, Berkeley, California, 1954), the world-renowned microbiologist Cornelis B.Van Niel, himself a pioneer in photosynthesis, was Phosphoglycerate kinase so impressed that he jumped from his front row seat to congratulate Calvin (see Benson 1995; Fuller1999). Thioctic acid involvement in the photochemical aspects of the quantum conversion of photosynthesis had

consumed at least 2 years of the laboratory’s time and enthusiasm and that of John Barltrop, who was visiting from the Department of Chemistry of the University of Oxford in England (Barltrop et al. 1954; Calvin 1954). The Laboratory’s interest in sulfur metabolism engendered my experiment with the green alga Chlorella cultured with radioactive S-35 sulfate and chromatography of the products. A major (>99%) S-35 labeled product appeared on the film in the location predicted for thioctic acid. Seeing this, Melvin’s eyes almost fell onto the white tabletop. He urged Clint Fuller to search the area with a sensitive bioassay for thioctic acid (Fuller 1999). Melvin’s interest heightened even further. I had been involved in successful efforts with J. Rodney(Rod) Quayle and R. Clint Fuller in demonstrating the function of a carboxylase enzyme for CO2 uptake in algae and photosynthetic bacteria.