Oxidized regenerated cellulose (Interceed) is a mechanical barrier that forms a gelatinous S63845 supplier protective coat and

breaks down and is absorbed within 2 weeks. This product has been studied in numerous Dorsomorphin prospective randomized studies in open or laparoscopic gynecologic surgeries. It has been shown to be safe and effective in reducing adhesions. The first study was a prospective, randomized, multicenter, clinical trial that evaluated the efficacy of Interceed in reducing adhesions in humans [165]. Infertility patients (n = 74) with bilateral pelvic sidewall adhesions were studied at treatment laparotomy and “”second-look”" laparoscopy to determine Interceed’s effectiveness. It did show a significant reduction of incidence, extent, and severity of postsurgical pelvic adhesions. In the second prospective, randomized, controlled clinical study, 21 women underwent a second-look laparoscopy 2-11 weeks after standardized laparoscopic electrosurgical treatment for polycystic ovarian

syndrome [166]. Following bilateral ovarian treatment, one ovary was randomly chosen to have Interceed applied to its surface using a specially designed applicator, with the other ovary serving as a control. Peri-adnexal adhesions of significant extent and severity developed in 57% of the women and 38% of the adnexa. The incidence of adhesions on the Interceed-treated side was 43%, while on the control side it was 33%. In addition, the extent and severity of the adhesions appeared to be similar on the Interceed-treated and control side. In a prospective randomized study of 134 women undergoing adhesiolysis by Doramapimod nmr laparotomy, and having applied Interceed on one sidewall and left the opposite side uncovered, the incidence and

severity of adhesions were evaluated at a second-look laparoscopy 10 days to 14 weeks after surgery and Interceed significantly reduced the incidence and extent of adhesions [167]. The Nordic Adhesion Prevention Study group in a multicenter, prospective, randomized, blinded study of 66 women undergoing adhesiolysis of 132 ovaries used Interceed around the adnexa on one side and left the other side uncovered. The incidence and severity of adhesions were assessed at a second-look laparoscopy 4 to 10 weeks after the initial surgery and the results all showed that Interceed significantly reduced the incidence, extent, and severity of adhesions [168]. A meta-analysis of 7 randomized studies showed that Interceed decreased the incidence of adhesions by 24.2% ± 3.3% (P < .001) when compared with untreated sites [169]. A more recent meta-analysis also concluded that Interceed reduced the incidence and severity of adhesions after open or laparoscopic gynecologic surgery [170]. Expanded polytetrafluoroethylene (Gore-Tex, Preclude; W.L. Gore & Associates, Hertogenbosch, The Netherlands): It is an inert, nonabsorbable permanent membrane that needs to be removed a few days after application.