J Bone Miner Res 24:1434–1449PubMedCrossRef 33. Heiland GR, Zwerina K, Baum W, Kireva T, Distler check details JH, Grisanti M, Asuncion F, Li X, Ominsky M, Richards W, Schett G, Zwerina J (2010) Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression. Ann Rheum Dis 69:2152–2159PubMedCrossRef 34. Mosley JR, March BM, Lynch J, Lanyon LE (1997) Strain magnitude related changes in whole bone architecture in growing rats. Bone 20:191–198PubMedCrossRef 35. Gross TS, Edwards JL, McLeod KJ, Rubin CT (1997) Strain gradients correlate with sites of periosteal bone formation. J Bone Miner Res 12:982–988PubMedCrossRef 36. Nicolella DP,
Bonewald LF, Moravits DE, Lankford J (2005) Measurement of microstructural strain in cortical bone. Eur J Morphol 42:23–29PubMedCrossRef 37. Nicolella DP, Moravits DE, Gale AM, Bonewald LF, Lankford J (2006) Osteocyte lacunae tissue strain in cortical bone. J Biomech 39:1735–1743PubMedCrossRef 38. Silvestrini G, Selleck CP673451 Ballanti P, Sebastiani M, Leopizzi M, Di Vito M, Bonucci E (2008) OPG and RANKL mRNA and protein expressions in the primary and secondary metaphyseal trabecular bone of PTH-treated rats are independent of that of SOST. J Mol Histol 39:237–242PubMedCrossRef 39. Yamane H, Sakai A, Mori T, Tanaka S, Moridera K, Nakamura T (2009) The anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs
depending on the remodeling status in bone in ovariectomized mice. Bone 44:1055–1062PubMedCrossRef 40. Gross TS, Rubin CT (1995) Uniformity Peptide 17 concentration of resorptive bone loss induced by disuse. J Orthop Res 13:708–714PubMedCrossRef 41. Gaudio A, Pennisi P, Bratengeier C, Torrisi V, Lindner B, Mangiafico RA, Pulvirenti I, Hawa G, Tringali G, Fiore CE (2010) Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab 95:2248–2253PubMedCrossRef 42. Mirza find more FS, Padhi ID, Raisz LG, Lorenzo JA (2010) Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal
women. J Clin Endocrinol Metab 95:1991–1997PubMedCrossRef 43. Kramer I, Loots GG, Studer A, Keller H, Kneissel M (2010) Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice. J Bone Miner Res 25:178–189PubMedCrossRef 44. Drake MT, Srinivasan B, Modder UI, Peterson JM, McCready LK, Riggs BL, Dwyer D, Stolina M, Kostenuik P, Khosla S (2010) Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women. J Clin Endocrinol Metab 95:5056–5062PubMedCrossRef 45. Sugiyama T, Saxon LK, Zaman G, Moustafa A, Sunters A, Price JS, Lanyon LE (2008) Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice.