In the recent year, timing for initiation of dialysis in advance CKD patients has been discussed widely, and there is a trend of not to dialysis patient solely depends LDE225 research buy on the level of GFR or serum creatinine. If patients have no life-threatening condition or without major uremic symptom/sign, it is suggested dialysis could be delayed. In Taiwan, it has been a rule to initiate dialysis at a very low level of GFR, no matter due to Insurance regulation or patient’s willing. Our unique experience in dialysis initiation could provide more information for other countries. LIEW ADRIAN Department of Renal Medicine,

Tan Tock Seng Hospital, Singapore As a renal replacement therapy, renal transplantation confers the best survival advantage over dialysis for the patient with end-stage renal disease (ESRD)1. The transplantation of these patients prior to the initiation of dialysis therapy, known widely as preemptive renal transplantation, offers the advantage of avoiding the complications, morbidities, and infrastructure and manpower

costs associated with dialysis access and therapy. The further argument for preemptive transplantation stems AT9283 ic50 from the unfavorable death rates among waitlisted patients compared with transplant recipients2. Indeed, large analyses of registry data, albeit retrospective in nature, had demonstrated that preemptive renal transplantation leads to considerable improvements in allograft and patient survival2,3, when compared to transplantation after a period of dialysis therapy. In fact, with incremental time on dialysis, the risk of graft loss and patient death after transplantation had been shown to increase linearly4. While the exact reasons for these improved outcomes with preemptive renal transplantation had not been clear, several observations had been made that could provide some information towards the contributing factors. Delayed graft function and biopsy-confirmed acute Protein kinase N1 rejection are well known to have negative effects on graft survival, and the association of preemptive transplantation with

lower rates of these occurrences5 could contribute to its superior outcomes noted in these large analyses. The low solute clearances associated with dialysis therapy expose patients to risks of accelerated atherosclerosis, malnutrition and chronic inflammation, which are adverse outcomes that can be avoided with preemptive transplantation5. Preemptive transplant recipients have also been found to have socioeconomic and demographic features that predict better outcomes, namely younger age, higher educational background, economic viability and fewer HLA antigen mismatches3,6. Furthermore, it had also been implied that preemptive transplantation alone could have direct beneficial effects on graft survival. The precise timing to proceed with preemptive transplantation remains controversial.