Genotype calls have been made by GeneMapper Software (version 4). Allele frequency of each microsatellite marker was calculated manually. Heterozygosity was determined by counting the heterozygotes in the female subset. We have shown that in 253 normal individuals from 20 different ethnic groups

of India, the heterozygosity for the markers ranged from 0.25 to 0.54; and for the entire subset of 102 female samples we could successfully discriminate between the two X-chromosomes using these five markers. These markers could also discriminate between the two X-chromosomes for each of 39 obligate carriers included in this study. In conclusion, this panel of five markers around the F8 locus can be used for carrier detection of HA with higher sensitivity across India selleck for families affected with the disease. “
“Radiosynovectomy (RS) is a very effective procedure that decreases both the frequency and the intensity of recurrent intra-articular bleeds related to joint synovitis. RS is currently recommended with 90Y for the knees and 186Rh for elbows and ankles. It can also be used in patients with inhibitors with minimal risk of complications. On average, RS has a 75–80% satisfactory outcome in the long term. Such efficacy can be measured clinically

by the decrease in the number Navitoclax of hemarthroses, with complete cessation for several years in some cases. In 20–25% Florfenicol of cases, RS fails to control hemarthroses, but in such cases, it can be repeated (up to three times with 6-month intervals). Global long-term results of treatment with chemical synovectomy (rifampicin and oxytetracycline) seem to be less favorable than with radionuclides (90Y, 32P, and 186Rh). Although the dose of radiation of RS is minimal and neither articular nor systemic neoplastic changes related to RS have been

reported so far, all patients must be counseled about malignancy concerns and given the opportunity to consider risk/benefit ratios. My current recommendation is to use RS in children older than 12 years of age. “
“Summary.  Moroctocog alfa (AF-CC) (Xyntha™, BDDrFVIII) is manufactured by a process designed to enhance the theoretical viral safety profile relative to ReFacto®, its predecessor, and to provide alignment with clinical monitoring by the one-stage clotting assay. To evaluate the efficacy and safety of B-domain-deleted recombinant factor VIII (BDDrFVIII) was given as bolus injection (BI) or continuous infusion (CI) in haemophilia patients undergoing major surgery. BDDrFVIII was administered by BI or CI per investigator discretion peri-operatively for at least 6 days. Thirty patients enrolled and were treated with at least one dose of BDDrFVIII. Twenty-five patients were evaluable for efficacy. Outcomes were favourable against a background of multiple major surgical procedures. All haemostatic efficacy ratings were ‘excellent’ or ‘good’.