Data were gathered on the patients’ demographics and clinical characteristics, including body mass index. Patients’ knowledge of hypertension was assessed using a 9-item instrument. Descriptive statistics was used to compute percentage frequency distributions of the variables. Inferential statistics employed Students’ t-test and one-way ANOVA at
95 % confidence interval.
Results: Females Semaxanib clinical trial were 131 (65.5 %), 138 (69.0 %) were either overweight or obese, 107 (53.5 %) had blood pressure >= 160/100 mmHg (Stage 2); 150 (75 %) did not know that hypertension is chronic and 132 (66 %) were not aware of risk of non-adherence. Poor knowledge of risk factors was associated with gender, marital status, income, and level of education (p < 0.05). Patients, 167 (83.5 %) received a combination of two antihypertensive medications with 88 (44 %) having thiazide diuretic as first line, and lifestyle modification was not an integral component of care.
Conclusion: Most patients received thiazide diuretic medication but not lifestyle education. Obesity was a common risk factor among the study group. Patients’ knowledge of hypertension was below average and they may need to be educated on hypertension and its effective
management using drugs and lifestyle changes.”
“The urothelium has been implicated in regulating VX-809 chemical structure detrusor smooth muscle contractility but the identity of the putative urothelium-derived inhibitory factor remains unconfirmed. There was inconclusive evidence on the role of
nitric oxide synthase (NOS) and cyclooxygenase (COX) in mediating detrusor contractions. This study examined varying regulation by NOS and COX in transverse and longitudinal carbachol (CCh)-induced and unstimulated phasic contractions. Methods: Rat detrusor strips with the urothelium-intact (+UE) and urothelium-denuded (-UE) were isolated in both transverse and longitudinal directions. Isometric tension of the detrusor strips was recorded both during stimulation with CCh and at the unstimulated state. In the unstimulated state, phasic contractile activity was measured. Tension recordings were made with and without the NOS inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME) and COX inhibitor indomethacin (Indo). Results: Only transverse +UE strips responded DAPT ic50 convincingly to L-NAME and Indo treatment, generating larger CCh-induced contractions. In unstimulated tissues, L-NAME treatment increased phasic amplitude in -UE strips only. Indo treatment failed to elicit any change in the amplitude but suppressed frequency of the phasic activity in transverse +UE strips. There was no significant Indo-mediated change in other strips. Conclusions: The data suggested heterogeneity in the regulation of directional detrusor contractility via NOS-and COX-associated mechanisms. Neurourol. Urodynam. 30:619-625, 2011. (C) 2011 Wiley-Liss, Inc.