Curcumin and eicosapentaenoic acid show efficacy in small clinical trials of FAP chemoprevention. This article will review the concept of chemoprevention and the current clinical literature in FAP chemoprevention. (C) 2011 Elsevier Ltd. All rights reserved.”
“Study
Design: A population-based study of suicides and linkage with national hospital discharge registers.
Objective: To investigate the prevalence of hospital-treated musculoskeletal diseases, particularly back pain (BP), among suicide victims to compare suicide characteristics between victims with and without musculoskeletal diseases, to analyze comorbidity between musculoskeletal diseases and psychiatric disorders, and to evaluate whether specific drugs have a role in suicides by poisoning.
Summary of Background Data: Depression, other
psychiatric disorders, and suicidal behavior are common comorbid conditions in patients with diseases of the musculoskeletal GSK461364 Cell Cycle inhibitor system.
Methods: The data consisted of 2310 suicides click here (1885 men and 425 women) committed in the province of Oulu in Northern Finland during 1988 to 2007. The information on hospital-treated musculoskeletal diseases (MSD) was extracted from the Finnish Hospital Discharge Registers. The suicide victims with a diagnosis of BP, including sciatica (BP, n = 133), and victims with MSD other than BP/MSD, n = 357) were compared with those of having no history of MSD (reference group, n = 1820). The data on suicides were based on death certificates that were taken from official medicolegal investigations.
Results: A total of 490 (21.3%) of suicide victims had a history of hospital-treated MSD. The age of death of the victims with BP was
about 11 years higher compared with the reference group. After adjusting for age, nonviolent suicide methods and use of analgesics in poisoning suicides SB525334 in vitro in both genders and hospital-treated depression/substance-related disorders in men were also more common in the BP and MSD groups. Women with BP had been more often under the influence of alcohol when committing suicide compared with the other groups.
Conclusion: Victims with a history of hospital-treated MSD committed suicide at older age. However, the older the person is, the more is the chance that he or she needs to have a treatment for some MSD at some point of life. Use of analgesics as a potential suicide method should be kept in mind when treating patients with musculoskeletal system diseases.”
“Colorectal cancer (CRC) is a major health concern worldwide. In 2011 1,200,000 new cases are predicted and half of them are going to die from the disease. CRC carcinogenesis is a multi-step process that spans over 10-20 years, providing a window of opportunity for effective intervention. CRC can be prevented by life style modification and screening program. However, although these strategies are standard clinical practice, their impact is limited due to low adherence.