CHL received her masters degree in nanotechnology from National C

CHL received her masters degree in nanotechnology from National Chiao Tung University (NCTU) in 2010. She is currently a candidate for doctor’s degree in materials Vorinostat nmr Science and engineering at NCTU. She was a teaching assistant with Hui Liang Wang group

in National Kaohsiung Normal University from 2006 to 2008. She has been a research assistant with the G. Steve Huang group in NCTU, where she studied the interaction and application of biology and nanotechnology interface, since 2008. Her current research interests include aging, cell signaling, bioelectronics, and the bio-nano interaction. She has presented two papers on nanoparticle neurotoxicity at international conference in Taiwan and Japan. She has polished three articles on magnetic field inducing aging in Caenorhabditis elegans. Androgen Receptor Antagonist YWC received her masters degree in nanotechnology from NCTU in 2013. Her research interests include bioelectronics and

the bio-nano interaction. Acknowledgements This work was partially supported by the ‘Aim for the Top University Plan’ of the National Chiao Tung University and the Ministry of Education, Taiwan. This work was also supported by NSC-SB RAS Joint Grant 100-2923-B-009-001-MY3 and Nanotechnology National project 101-2120-M-009-008 of the National Science Council, Taiwan, AG-881 ic50 and a National Health Research Institute grant (NHRI-EX102-10249EI). References 1. Fields RD, Stevens-Graham B: Neuroscience – new insights into neuron-glia communication. Science 2002, 298:556–562.CrossRef 2. Turner AMP, Dowell N, Turner SWP, Kam L, Isaacson M, Turner JN, Craighead HG, Shain W: Attachment

of astroglial cells to microfabricated pillar arrays of different geometries. J Biomed Mater Res 2000, 51:430–441.CrossRef 3. Kaech S, Banker G: Culturing hippocampal neurons. Nat Protoc 2006, 1:2406–2415.CrossRef 4. Zhu BS, Zhang QQ, Lu QH, Xu YH, Yin J, Hu J, Wang Z: Nanotopographical guidance of C6 glioma cell alignment and oriented growth. Biomaterials 2004, 25:4215–4223.CrossRef 5. Baranes K, Chejanovsky N, Alon N, Sharoni A, Shefi O: Topographic cues of nano-scale height direct neuronal growth pattern. Biotechnol Bioeng BCKDHA 2012, 109:1791–1797.CrossRef 6. Kim P, Kim DH, Kim B, Choi SK, Lee SH, Khademhosseini A, Langer R, Suh KY: Fabrication of nanostructures of polyethylene glycol for applications to protein adsorption and cell adhesion. Nanotechnology 2005, 16:2420–2426.CrossRef 7. Choi CH, Hagvall SH, Wu BM, Dunn JCY, Beygui RE, Kim CJ: Cell interaction with three-dimensional sharp-tip nanotopography. Biomaterials 2007, 28:1672–1679.CrossRef 8. Curtis AW, Wilkinson C: Nanotechniques and approaches in biotechnology. Mater Today 2001, 4:22–28.CrossRef 9. Dunn GA: How do cells respond to ultrafine surface contours. Bioessays 1991, 13:541–543.CrossRef 10.

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