Cancer Chemother Pharmacol 2010, 66:433–439.Akt inhibitor PubMedCrossRef 7. Chauhan D, Anderson KC: Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications. Apoptosis 2003, 8:337–343.PubMedCrossRef 8. Reed JC, Miyashita T, Takayama S, Wang HG, Sato T, Krajewski S, et al.: BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 1996, 60:23–32.PubMedCrossRef 9. Reed JC: Bcl-2 family proteins:

regulators of apoptosis and chemoresistance in hematologic malignancies. Semin Hematol 1997, 34:9–19.PubMed 10. Real PJ, Cao Y, Wang R, Nikolovska-Coleska Z, Sanz-Ortiz J, Wang S, et al.: Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2. Cancer Res 2004, 64:7947–7953.PubMedCrossRef 11. Oltersdorf T, Elmore SW, Shoemaker Small molecule library LY2606368 molecular weight AR, Armstrong RC, Augeri DJ, Belli BA, et al.: An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005, 435:677–681.PubMedCrossRef 12. Johnstone RW, Cretney E, Smyth MJ: P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999, 93:1075–1085.PubMed 13. Smyth MJ, Krasovskis E, Sutton VR, Johnstone RW: The drug efflux protein, P-glycoprotein, additionally

protects drug-resistant tumor cells from Protirelin multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci USA 1998, 95:7024–7029.PubMedCrossRef 14. Ruefli AA, Smyth MJ, Johnstone RW: HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood 2000, 95:2378–2385.PubMed 15. Shtil AA, Grinchuk TM, Tee L, Mechetner EB, Ignatova TN: Overexpression of P-glycoprotein is associated with a decreased mitochondrial transmembrane potential in doxorubicin-selected K562 human leukemia cells. Int J Oncol 2000, 17:387–392.PubMed 16. Hu M, Liu Y, Deng C, Han R, Jia Y, Liu S, et al.: Enhanced invasiveness in multidrug resistant leukemic cells is associated with overexpression of P-glycoprotein

and cellular inhibitor of apoptosis protein. Leuk Lymphoma 2011, 52:1302–1311.PubMedCrossRef 17. Lavie Y, Cao H, Bursten SL, Giuliano AE, Cabot MC: Accumulation of glucosylceramides in multidrug-resistant cancer cells. J Biol Chem 1996, 271:19530–19536.PubMedCrossRef 18. Lucci A, Cho WI, Han TY, Giuliano AE, Morton DL, Cabot MC: Glucosylceramide: a marker for multiple-drug resistant cancers. Anticancer Res 1998, 18:475–480.PubMed 19. Yamashita T, Wada R, Sasaki T, Deng C, Bierfreund U, Sandhoff K, et al.: A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci USA 1999, 96:9142–9147.PubMedCrossRef 20. Lavie Y, Cao H, Volner A, Lucci A, Han TY, Geffen V, et al.