As shown in Table 1, multivariate risk analysis showed that only MLR is an independent prognostic factor. Patients with a higher MLR suffered a higher death risk (RR = 2.801,
P = 0.000, 95% CI: 1.680 – 4.668)(Table 2). Figure 2 Survival curves of patients in different MLR groups. Table 1 Influence of clinicopathological characteristics on the prognosis in 121 gastric adenocarcinoma patients. Characteristics Samples Five-year survival (%) Log-rank (X 2 value) P value Gender (male/female) 77/44 35.5/49.5 0.527 0.468 Lauren type Intestinal type 109 46.1 6.322 0.012 Diffuse type 12 0 Type of histology 1–2 75 40.5 0.000 0.990 3 46 40.0 Lymphatic vessel invasion
Negative 54 60.6 14.199 0.000 Positive 67 18.3 Blood vessel invasion Negative 100 43.7 13.455 0.000 Positive 21 28.8 Lymph nodes metastasis Negative AMN-107 purchase 44 79.0 24.919 0.000 Positive 77 13.0 Depth of invasion T1 18 94.1 25.835 0.000 T2 31 56.0 T3 31 36.7 T4 41 0 N stage (UICC) N0 43 78.9 34.320 0.000 N1 44 22.1 N2 24 0 N3 10 0 N stage (JRSGC) N0 42 78.9 38.976 0.000 N1 38 12.6 Histone Acetyltransferase inhibitor N2 31 16.4 N3 10 0 MLR MLR1 43 78.9 36.575 0.000 MLR2 20 32.7 MLR3 58 0 Table 2 Multivariate risk analysis of 121 gastric adenocarcinoma patients. Characteristics B S.E. Wald df Sig. Exp (B) 95.0%(CI)) Lauren type 0.901 0.439 4.218 1 0.04 2.462 1.042 – 5.819 Depth of invasion 0.684 0.223 9.397 1 0.002 1.981 1.280 – 3.067 MLR 1.030 0.261 15.610 1 0.000 2.801 1.680 – 4.668 Correlation between MLR and N stage in gastric adenocarcinoma As shown in Table 3, patients with the same
N stage may be in different MLR groups. Moreover, in N2 stage (JRSGC classification), differences in the patients’ prognosis were seen among the different MLR groups (X 2 = 4.372, P = 0.037) (Figure 3A). Similarly, in N1 stage (UICC classification), differences were also observed (X 2 = 4.320, P = 0.038) (Figure 3B). Figure 3 Survival curves in patients with the same N stage, but in different MLR groups. A. N2 stage (JRSGC classification); B. N1 (UICC classification). Table 3 Correlation between MLR and N stage in gastric adenocarcinoma. oxyclozanide MLR groups [n (%)] MLR groups [n (%)] N stage (UICC) Samples MLR1 MLR2 MLR3 N stage (JRSGC) Samples MLR1 MLR2 MLR3 N0 43 43(100) N0 43 43(100) N1 44 19(43.2) 25(56.8) N1 38 16(42.1) 22(57.9) N2 24 1(4.2) 23(95.8) N2 30 4(13.3) 26(86.7) N3 10 10(100) N3 10 10(100) Effects of lymph node micrometastasis on the MLR in gastric adenocarcinoma Lymph node micrometastasis was identified as a metastatic focus ranging from 0.2 to 2 mm in diameter and was mainly located at the marginal sinus with a nonclustered or clustered distribution. Occasionally, some were also observed at the medulla or cortex.