Although these studies are incomparable with respect to design, CT scanners used, diagnostic work-up protocols and SKI-606 in vivo trauma populations[26], the main conclusion is clear. Total-body CT scanning in trauma patients is not as time consuming as was once expected and may even be time saving compared to conventional imaging protocols

supplemented with selective CT. The most important question remains whether immediate total-body CT scanning will translate to improved clinical outcome. A recent study in 4621 trauma Inhibitors,research,lifescience,medical patients reported a significant increase in the probability of survival for patient given immediate total-body CT scanning compared with conventional imaging strategies supplemented with selective CT scanning [25]. However, Inhibitors,research,lifescience,medical since the study was retrospective in nature, no correction for all confounding variables could have been made. Patients who underwent immediate total-body CT scanning were on average more severely injured than those who did not receive total-body CT scanning. Differences between participating centers and protocols used for diagnostic work-up were not described. Whether the positive effect in survival in patients who underwent total-body CT scanning can be attributed solely to the total-body CT scan itself remains therefore unclear. Although

literature Inhibitors,research,lifescience,medical provides limited evidence for the usage of an immediate total-body CT scan in the work-up of trauma patients, more and more trauma centers encourage and are implementing immediate total-body CT scanning

in the diagnostic phase of primary trauma care. Since the burden of total-body Inhibitors,research,lifescience,medical CT scanning in terms of costs and radiation dose is at least controversial [20,27,28], the advantage of performing an immediate total-body CT scan should be proven in high quality studies resulting in high level evidence in order to make its implementation justifiable. In order to assess the value of immediate total-body CT scanning in severely injured trauma patients, Inhibitors,research,lifescience,medical the Academic Medical Center (AMC) in Amsterdam, the Netherlands, has initiated an international multicenter randomized controlled trial. Severely injured patients, who are thought to benefit the most from a total-body imaging concept, Resminostat will be included. Such a trial has never been done before and is crucial to provide evidence whether or not the usage of immediate total-body CT scanning in the diagnostic phase of primary trauma care is justifiable. Methods/design Study objectives The primary objective is to determine the effects of immediate total-body CT scanning during the primary trauma survey on clinical outcomes compared to patients who are evaluated with standard conventional Advanced Trauma Life Support (ATLS®) based radiological imaging.