Although almost the entireAIM +ve group experienced hallucinations (13/16), this did not differ significantly from the AIM -ve group (14/25) (Table 3). However, the AIM +ve group was statistically more likely to experience symptoms in more than one domain (p = 0.05 two-tailed) (Table 3). Table 3. Symptoms in relation to abnormal movement. In the treatment of relapse, the AIM +ve patients were half as likely as the AIM -ve patients to have their medication increased (p = 0.06 two-tailed) (Table 4). The groups did not differ in terms of admission, social or psychotherapeutic Inhibitors,research,lifescience,medical care. Table 4. Treatment change at relapse. The outcome

at follow up (see Table 5) revealed two statistically significant differences between the two samples. The AIM Inhibitors,research,lifescience,medical +ve patients were statistically more likely to have residual symptoms between episodes (11/14 AIM +ve versus 8/25 AIM -ve; p = 0.008 two-tailed) and make a worse recovery at 6 month follow up (3/14 had made a full recovery at 6 months compared with 18/25; 2 × 3 chi square p = 0.05). These findings Doxorubicin nmr remained significant when the possible confounding effects of life events were removed by comparing the AIM groups in those without life events. Table 5. Outcomes at follow up. Discussion Inhibitors,research,lifescience,medical This study had five aims. The first aim was to discover if the

cause of psychotic relapse in 41 individuals relapsing without any obvious precipitants could be determined by using the checklist and a review of clinical records. The second was to determine whether any of the participants exhibited AIM evidence of dopamine supersensitivity. It was found that 39% (16/41) Inhibitors,research,lifescience,medical of patients met the criteria for supersensitivity psychosis, a figure comparable to the earlier study by Fallon and Dursun that found 32% met the criteria [Fallon and Dursun, 2011]. A further group of 41.5% (17/41) had an identifiable life event prior to relapse that could have been implicated in the relapse. Of these two groups only four patients had both abnormal movements and a life event. If this Inhibitors,research,lifescience,medical result (10%) was adjusted for the

assessment still identified a cause of relapse for 71% of patients. Therefore, the clinical checklist was able to identify a cause of relapse for PD184352 (CI-1040) a significant proportion of the sample and specifically was able to identify the presence of supersensitivity psychosis in a significant number of them. The group with supersensitivity psychosis differed from the rest of the sample in several respects (third aim). As well as displaying AIMs, they exhibited several other features that could reflect dopamine supersensitivity and breakthrough of symptoms. They experienced more psychotic symptoms at relapse, they were more likely to experience residual symptoms, and had worse outcomes at 6 months follow up. They were also statistically more likely to live in residential care, which may be a reflection of their greater degree of chronicity.