73 m-2) were NPT patients.Table selleck bio 2Comparison of patients with different measured creatinine clearance (CLCR)Patients with CLCR greater than 120 mL minute-1 1.73 m -2 were younger (40 �� 16 years vs 56 �� 18 years), had a lower SAPS II score (43 �� 14 vs 50 �� 15) and a higher male ratio as compared with patients presenting a CLCR lower than 120 mL minute.All factors presenting a statistical difference between hyperfiltration and hypofiltration subgroups (Table (Table2)2) were analyzed. Through a logistic regression analysis, including goodness of fit of the model, age and trauma were the only factors independently correlated to CLCR (Table (Table33).

Table 3Logistic regression for different measured creatinine clearanceDiscussionThe present results comparing a population of hemodynamic stable PT patients to a population of hemodynamic stable NPT patients with steady state serum creatinine concentration with a normal creatinine serum value demonstrate that (i) PT patients exhibit dramatic variations of their CrCl; (ii) CrCl is higher in PT patients than in NPT patients; (iii) Age and trauma are independently correlated factors to CLCR in our study and in these study conditions.Considering serum creatinine values, no significant difference was found between PT and NPT groups despite the variations of CrCl. These data demonstrated that a wide range of measured CLCR variations exists and, therefore, confirm Hoste data obtained in critically ill patients with serum creatinine within normal range [16]. These authors demonstrated that “serum creatinine has a low sensitivity for detection of renal dysfunction”.

Our results also revealed some opposite trends between CrCl and creatinine measurements, as some patients had significantly lower values of serum creatinine for CLCR > 60 mL minute-1 1.73 m-2 than for CLCR < 60 mL minute-1 1.73 m-2. These data underline the inaccuracy of serum creatinine values in estimating the renal function.Fifty-five percent of PT patients, and only 19% of NPT patients presented a measured CLCR above 120 mL minute-1 1.73 m-2. In addition, only 10% of PT patients vs 34% of NPT patients presented a measured CLCR below 60 mL minute-1 1.73 m-2. In clinical practice, the diagnosis of increased CLCR as a surrogate marker of GFR is important and has largely been demonstrated in burn patients in the setting of antibiotics monitoring: ceftazidime, cefepime, vancomycin and amikacin [4,5,17,18].

In critically ill patients, high CLCR required high doses of drugs, which are eliminated by the kidneys to obtain therapeutic concentration. Recently we confirmed the need for CLCR monitoring in order to accurately monitor renal function and, therefore, to optimize the doses of antibiotics [4,19].Our results demonstrate that age, gender, ideal body weight, severity index, trauma patients, and serum creatinine are factors for a CLCR Dacomitinib above normal (> 120 mL minute-1 1.