The reference point of 1800 was therefore accepted as approaching pristine conditions for the purpose of the SoE Antidiabetic Compound Library reporting system, and is consistent with the most reliable form of a utility function for estimating declines in natural populations (Borja et al., 2012, Porszt et al., 2012 and McClenachan et al., 2012). Reference points for determining condition quality are not posited here as management targets, although they may coincide for

some purposes. The components assessed here do not have complete fidelity to a biodiversity parameter (sensu Table 1), but the allocation in this typology explicitly guides the interpretation and decision model underpinning the scores/grades. For example, algal blooms

may be considered as a pressure on marine ecosystems as well as a productivity resource. In the typology used here, algal blooms are assessed from the perspective that, relative to the reference point, increasing blooms (numbers, distribution, persistence) are a symptom of declining environmental condition and biodiversity quality. To ensure a consistent interpretation of scoring and grading, the grading statements ( Table 2) elaborate the characteristics of each of the four performance bands, and establish the scoring/grading thresholds. Ivacaftor price Also, several of the experts attended all workshops to assist with maintaining consistent interpretations of both the typology and the scoring guidelines among workshops. During the workshops participants assigned a group consensus confidence estimate for each component of both condition and trend, as High, Medium or Low, and in addition, Anacetrapib a no-score option was available. This estimate is intended to capture all forms of uncertainty (sensu Walker et al., 2003) around the assignment of a grade, including issues of surrogacy. When experts were confident about a score that had been assigned, and considered that it would be highly unlikely that

a more accurate estimate (by say, subsequent capture of appropriately designed field data) would fall outside the grade to which it had been assigned at the workshop, then a grade of High confidence was applied. Medium confidence was applied when it was considered that an accurate estimate of the score would fall within the grade adjacent to the one to which the condition (or trend) had been assigned at the workshop, and Low confidence was assigned when the grade was based on some information but was even less certain than Medium. The no-score option for confidence was used when either the component did not occur in the region in a substantive way or there was insufficient information available to the assessment process to make a judgement that fits one of the three grades.