Serial clinical data and plasma BNP measurements were obtained du

Serial clinical data and plasma BNP measurements were obtained during the first trimester, third

trimester, and after delivery (>6 weeks).\n\nResults Seventy-eight pregnant women were studied; 66 women with heart disease (age 31 +/- 5 years), and 12 healthy women (age 33 +/- 5 years). During pregnancy, the median peak BNP level was higher in women with heart disease compared with control subjects (median 79, interquartile range 51 to 152 pg/ml vs. median 35, interquartile range 21 to 43 pg/ml, p < 0.001). In women with heart disease, those with subaortic ventricular dysfunction had higher BNP levels (p = 0.03). A BNP >100 pg/ml was measured in all women with events during pregnancy (n = 8). Sixteen women had increased BNP levels during pregnancy but did not have clinical Ro-3306 datasheet events. None of the women with BNP <= 100 pg/ml had events. BNP <= 100 pg/ml had a negative predictive value of 100% for identifying events during pregnancy.\n\nConclusions CP-868596 clinical trial Many pregnant women with heart disease have increased BNP levels during pregnancy. Incorporating serial BNP levels in into clinical practice can be helpful, specifically in adjudicating

suspected adverse cardiac events during pregnancy. (J Am Coll Cardiol 2010;56:1247-53) (C) 2010 by the American College of Cardiology Foundation”
“Background\n\nUp to 1% of adults will have a leg ulcer at some time.\n\nThe majority of leg ulcers are venous in origin and are caused by high pressure in the veins due to blockage or weakness of the valves in the veins of the leg. Prevention and treatment of venous ulcers is aimed at reducing the pressure either by removing/repairing the veins, or by applying compression bandages/stockings to reduce the pressure in the veins. The majority of venous ulcers heal with compression bandages, however ulcers frequently recur.

Clinical guidelines therefore recommend that people continue to wear compression, usually in the form of hosiery (tights, stockings, socks) after their ulcer heals, to prevent recurrence.\n\nObjectives\n\nTo assess the effects of compression (socks, stockings, tights, bandages) in preventing the recurrence DAPT of venous ulcers. If compression does prevent ulceration compared with no compression, then to identify whether there is evidence to recommend particular levels of compression (high, medium or low, for example), types of compression, or brands of compression to prevent ulcer recurrence after healing.\n\nSearch methods\n\nFor this update we searched The Cochrane Wounds Group Specialised Register (searched 1 March 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2); Ovid MEDLINE (1950 to February Week 4 2012); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, February 29, 2012); Ovid EMBASE (1980 to 2012 Week 08); and EBSCO CINAHL (1982 to 1 March 2012).

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