For females, however, neither recollection nor familiarity appeared to be influenced
by daytime sleep.
The mechanism underlying gender difference may Omipalisib ic50 be linked with different memory traces resulting from different encoding strategies, as well as with different electrophysiological changes during daytime sleep.”
“Aims: Gender differences are known to occur in the pharmacokinetics of many drugs. Mechanisms may include differences in body composition, body weight, cardiac output, hormonal status, and use of different co-medications. Recently subtle gender-dependent differences in cytochrome P450 (CYP) 3A-dependent metabolism have been demonstrated. Buprenorphine N-dealkylation to norbuprenorphine is primarily performed by CYP3A. We therefore asked whether gender-dependent differences occur in the pharmacokinetics of buprenorphine.
Methods: A retrospective examination was made of control (buprenorphine/naloxone-only) sessions from a number of drug interaction studies between buprenorphine and antiretroviral drugs. Twenty males and eleven females were identified who had a negative cocaine urine test prior to participation in the control session and were all on the same maintenance dose (16/4 mg) of sublingual buprenorphine/naloxone. Pharmacokinetic
data from their control sessions (buprenorphine/naloxone only) were sorted by gender and compared using the two-sample t-test.
Results: Females had significantly higher area under the PLX3397 chemical structure plasma concentration curve (AUC) and maximum plasma concentrations for buprenorphine, norbuprenorphine and norbuprenorphine-3-glucuronide. AUCs relative to dose per body weight and surface area were significantly higher for only norbuprenorphine. AUCs relative to lean body mass were, however, not significantly different.
Conclusions: Gender-related differences exist in the pharmacokinetics of buprenorphine; differences in body composition appear to have a major impact;
selleck chemicals differences in CYPA-dependent metabolism may also contribute. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Waterborne polyurethane (PU) was prepared by the prepolymer mixing method with (3-aminopropyl)triethoxysilane in different dosages as the modifier. Then, it was mixed with poly(vinyl alcohol) (PVA) to get waterborne PU/PVA blending membranes. The membranes showed phase separation with the aggregations of the waterborne PU particles in a continuous phase of PVA. The possible cause for the formation of such a membrane morphology is explained. The physicochemical properties of the membranes were characterized. As the PVA content increased, the membrane’s swelling in water and the thermal stability decreased somehow, whereas the resistance to ethanol and the tensile strength were significantly improved.