One possibility is a specific discussion on this issue at the beginning and during the process of the guidelines work. Furthermore in case of potential conflicts of interest a solution as e. g. abstention from voting on specific questions

needs to be developed.”
“The HfO2 Ilomastat solubility dmso films were prepared using alkoxy-derived precursor solutions. The effects of the chemical composition of precursor solutions on the microstructure development and electrical properties were investigated. The flatness and refractive index of the HfO2 films were improved by using diethanolamine-added solution. This result is considered to be due to the difference in the progress of organic decomposition and the behavior of nucleation and grain growth. The difference in the chemical composition affected the electrical properties such as leakage current and capacitance-voltage characteristics, which are related to the defects in the film and interface state.”
“OBJECTIVE: To assess whether pleural fluid analysis (PFA) can confidently diagnose tuberculous pleural effusion (TPE).

METHODS: PFA of 548 TPEs was performed between January 1991 and December 2011. The control group consisted of patients with malignant PE (MPE), complicated parapneumonic/empyema selleck inhibitor (infectious) PE (IPE), miscellaneous PE (MisPE)

and transudative PE (TrPE).

RESULTS: The PFA of 548 histologically or culture-positive consecutive cases of TPE was compared with that of 158 consecutive cases of MPE, 113 cases of IPE, 37 cases of MisPE and 115 cases of TrPE. Statistically significant differences were noted in pleural fluid glucose, pH, cholesterol, triglycerides, adenosine deaminase (ADA), and total percentages of lymphocytes, neutrophils and macrophages when TPEs were compared to all other groups. Of the TPEs, 99.1% were exudates. Pleural fluid protein >= 5.0 g/dl, lymphocytes > 80% and ADA > 45 U/l were diagnostic

of TPE, with a specificity of 100%, a sensitivity of 34.9% and an area under the curve of 0.975.

CONCLUSION: PFA alone was diagnostic in one third of the TPE cases, with a high probability in nearly 60%.”
“Facial eczema is a common disease in daily dermatological practice. The cause of facial eczema is often atopic dermatitis or allergic contact Entinostat in vivo dermatitis. Usually, the eczema resolves with correct topical treatment and by avoiding allergic trigger factors. A 49-year-old woman presented with persistent eczema on her forehead which recurred over decades despite correct topical therapy. A skin biopsy revealed the astonishing diagnosis of a nevus flammeus with an overlying eczema known as the Meyerson phenomenon. The Meyerson phenomenon is often described in children with nevi flammei suffering from atopic dermatitis – in adults the phenomenon is rarely recognized as a reason for eczema. We show the interesting case of an adult woman with the Meyerson phenomenon on a nevus flammeus and discuss the possible pathomechanisms.

Methods: From a series of 303 microsurgically clipped saccular cerebral aneurysms, 40 aneurysms were identified at sites not related to a branch vessel. Results: The distribution of aneurysms at nonbranching sites

was internal carotid: 21 of 40 (52.5%); main stem of the middle cerebral artery/secondary branch of the middle cerebral artery: 6 of 40 (15%); anterior cerebral BX-795 mouse artery: 1 of 40 (2.5%); pericallosal artery: 1 of 40 (2.5%); pericallosal/callosal marginal: 3 of 40 (7.5%); vertebral artery: 1 of 40 (2.5%); posterior cerebral artery: 1 of 40 (2.5%); posterior cerebral artery/secondary branch of the posterior cerebral artery: 1 of 40 (2.5%); anterior inferior cerebellar artery: 1 of 40 (2.5%); and distal posterior inferior cerebellar artery: 1 of 40 (2.5%). Branch vessels were seen in 5 cases, and small perforating vessels were observed in 2 instances. Conclusions: Saccular aneurysms occurring at nonbranching sites are uncommon. Their geometry is particularly favorable selleck for flow directed stents and is most amenable to aneurysms located on large-diameter conducting vessels such as the internal carotid, vertebral,

and vertebrobasilar vessels. Smaller parent arteries harboring this type of aneurysm will require new technology to maintain patency of these more distal vessels. If endovascular techniques cannot achieve aneurysm sac obliteration, then open craniotomy and aneurysm clipping will provide a satisfactory alternative.”
“In terms of treatment outcome, little prognostic power is attributed to day-4 morphology. A day-4 score was applied to 56 patients separating non-compacting embryos from SBE-β-CD compacting (some areas of compaction) and fully compacted embryos. The latter were further subdivided according to the morphology of compaction. Grade C1 embryos represented optimal quality, while grades C2 (exclusion of fragments) and C3 (exclusion of blastomeres)

were characterized by a loss of cytoplasm. Grade 4 embryos (C4) showed incomplete compaction with several blastomeres not yet incorporated into cell mass. Pooled embryos without compaction showed a reduced (P < 0.001) blastulation (28.8%) as compared with compacting embryos with the same cell number (68.8%), which, ill turn. revealed lower (P < 0.05) rates of blastulation as compared with concepti that completed compaction process (84.6%). Anion fully compacted embryos grade C1 had a better (P < 0.01) blastocyst formation rate (94.4%) as compared with grade C3 (68.2%). Grade C1 embryos showed significantly higher rates of top-quality blastocysts as compared with grade C2 (P < 0.05) and C3 (P < 0.01). Blastocysts deriving from grade C1/C4 embryos led to a higher pregnancy rate as compared with the C2/C3 counterparts (P < 0.05). This modified score allows for adequate prediction of both blastocyst formation/quality and pregnancy.

It has, however, remained central to the palliation of neonates with complex congenital heart disease. The indications have expanded from the original aim of alleviating cyanosis and the pathophysiological results of chronic hypoxemia. They now include lesions with single ventricles, and rehabilitation of small pulmonary arteries. The physiology and hemodynamics of BT shunt circulations are very complex, and adverse hemodynamic events can be difficult to recognize. The consequences of shunt failure can

be fatal, and the mortality (3-15%) and morbidity remain distressingly high even in the current era. Neonates undergoing BT shunt procedures or undergoing noncardiac surgery with this anatomy are challenging for the anesthesiologists to manage. There is a significant incidence of periprocedural cardiac arrest, often related to myocardial ischemia. A clear understanding of the anatomy and JNK animal study physiology is important. Any discussion of BT shunt in the current era has to include consideration of hypoplastic left heart syndrome and

single selleck ventricle’ physiology.”
“Linezolid is an antibiotic used to treat highly resistant infections, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. Enterococcus faecalis bacteremia occurs in pediatric patients. We present a teenager admitted for bacteremia caused by E. faecalis with a distinctive pattern of resistance to linezolid. This organism has the highest MIC to linezolid reported in the literature to date.”
“This paper describes the career path of one woman scientist and identifies the factors that promote a productive and rewarding career. Factors include a strong personal interest in the area of study, mentorship at all stages of development, collaborative relationships with colleagues in and beyond one’s discipline, and family and social support. A career focused on understanding the

role of stress in gastrointestinal distress is described.”
“Background:

There are only limited data on post-transplant ascites unrelated to small-sized grafts in living donor liver transplantation (LDLT).

Methods:

The subjects were 59 adult patients who had received right lobe LDLT with a graft weight-to-recipient weight ratio (GRWR) > click here 0.8%. Patients were divided into either Group 1 (n = 14, massive ascites, defined as the production of ascitic fluid > 1000 mL/d that lasted longer than 14 d after LDLT) or Group 2 (n = 45, no development of massive ascites). Patients were followed for a median period of 3.0 yr (range, 0.5-7.5 yr).

Results:

Group 1 had both higher Model for End-Stage Liver Disease score and Child-Pugh score than Group 2. Portal venous flow volume just after reperfusion was significantly greater in Group 1 than Group 2 (307.8 +/- 268.8 vs. 176.2 +/- 75.0 mL/min/100 g graft weight, respectively; p < 0.05).

For example, more than 35 susceptibility loci have been identified for type 2 diabetes and 32 for obesity thus far. However, the causal gene and variant at a specific linkage disequilibrium block is often unclear. Using

a combination of different mouse alleles, we can greatly facilitate the understanding of which candidate gene at a particular disease locus is associated with the disease in humans, and also provide functional analysis of variants through an allelic series, including analysis of hypomorph and hypermorph point mutations, and knockout and overexpression alleles. The phenotyping https://www.selleckchem.com/products/ferrostatin-1-fer-1.html of these alleles for specific traits of interest, in combination with the functional analysis of the genetic variants, may reveal the molecular and cellular click here mechanism of action of these disease

variants, and ultimately lead to the identification of novel therapeutic strategies for common human diseases. In this Commentary, we discuss the progress of GWAS in identifying common disease loci for metabolic disease, and the use of the mouse as a model to confirm candidate genes and provide mechanistic insights.”
“Tissue transplantation is a well-established tool for the treatment of degenerative and malignant disorders, yet its use in clinical practice is hampered by the need for human-leukocyte-antigen-compatible donors and a shortage of suitable graft tissue. The discovery of human embryonic stem cells a decade ago raised hopes that a universal resource for the cell-based treatment of various conditions would soon become available. embryonic stem cells derived by somatic-cell nuclear transfer or parthenogenesis can provide human-leukocyte-antigen-matched cells, which

may be transplanted without the need for immunosuppressive treatment. However, technical hurdles and ethical concerns about use of oocytes and involvement of embryos have Selleckchem R428 limited the clinical use of these cells. An alternative approach involves adult somatic cells being reprogrammed to enter a pluripotent state. such manipulation of these readily available cells has enabled derivation of patient-specific, pluripotent stem-cell lines, without progression through the blastocyst stage. This review critically analyzes the currently available methods for the generation of pluripotent stem cells, and discusses prospects for their clinical use.”
“We present a systematic computational analysis of the complex, electromechanically driven surface dynamics of voids in thin films of face-centered cubic metals for < 100 >-oriented film planes characterized by four-fold symmetry of surface diffusional anisotropy. The voids are located at an edge of the metallic thin film, and the film is subjected simultaneously to an external electric field and an anisotropic biaxial tensile stress.

“
“Green, white and black teas were assayed for inhibition of pancreatic lipase activity in vitro. White tea proved to be more effective than green tea with black tea showing little inhibition even at 200 mu g GAE/ml. The EC(50) values for inhibition were 22 mu g/ml for white tea and 35 mu g/ml for green tea: both easily achievable from normal infusions of tea. Liquid chromatography-mass spectroscopy analysis showed that white and green teas had essentially equal amounts of flavan-3-ols but green tea had higher levels ALK activation of flavonols. White tea had higher levels of 5-galloyl quinic

acid, digalloyl glucose, trigalloyl glucose and the tannin, strictinin.

After chromatography on Sephadex LH-20, the main inhibitory fraction was enriched in strictinin and fractions enriched in other components were ineffective. This suggests that strictinin content may be crucial for inhibition

of pancreatic lipase. However, the possibility of synergies between the polyphenols cannot be disregarded. Crown Copyright (C) Pifithrinα 2010 Published by Elsevier Ltd. All rights reserved.”
“Objective-To measure thiamine concentrations in commercial canned foods formulated for cats as an initial assessment of the variation among canned foods and to determine the effects of flavor (fish vs nonfish) of the food, texture (pate vs nonpate) of the food, country of manufacture, and check details size of the company on thiamine concentration.

Design-Prospective cross-sectional study.

Sample-90 canned, nontherapeutic diets formulated for cats (1 fish and 1 nonfish flavor for each of 45 brands).

Procedures-Each canned food was homogenized, and thiamine concentration was analyzed with a fluorometric method.

Results-Thiamine concentration was below the minimums of the Association of American Feed Control Officials in 12 of 90 (13.3%) foods and below the recommended allowance of the National Research

Council in 14 of 90 (15.6%) foods. Pate foods had significantly lower thiamine concentrations than did nonpate foods, and foods from smaller companies had significantly lower thiamine concentrations, compared with concentrations in foods from larger companies. Flavor of food and country of manufacture were not significantly associated with thiamine concentration.

Conclusions and Clinical Relevance-A wide range of thiamine concentrations was found in the foods evaluated. Thiamine concentration in a substantial percentage of commercially available canned foods was below the amount recommended for adult cats. Additional research on interlot and intralot variation in thiamine concentrations of foods formulated for cats is warranted. Companies should implement strict quality control and analysis practices regarding food products.

The cut points for detecting all heavy drinkers (including binge drinkers without exceeding weekly thresholds) were lower than for detecting heavy drinkers excluding those who are only binge drinkers. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“The surge in dopamine in ventral

striatal regions in response to drugs of abuse and drug-associated stimuli is a final common pathway of addiction processes. find more GABA B agonists exert their effects indirectly, by quieting dopaminergic afferents. The ability of the GABA B agonist, baclofen to ameliorate nicotine and drug motivated behavior is established within the animal literature, however its potential to do so in humans is understudied, particularly with respect to its possible utility as a smoking cessation agent.

We conducted a nine-week double-blind placebo-controlled pilot trial of baclofen for smoking reduction (N = 30/group) in smokers contemplating, but not quite ready to quit. Baclofen was titrated upwards to 20 mg q.i.d. over a period of twelve days. The primary outcome measure was the number of cigarettes smoked per day (CPD).

A significant

group by time effect of medication was observed. Baclofen was superior to placebo in reducing CPD (P = 0.01, t = KPT-8602 supplier 1.97, p < 0.05). The most common side effect reported during baclofen treatment is transient drowsiness, however there were no differences between groups in mild, moderate, or severe sedation. Craving was significantly lowered at end of treatment in all smokers (p < EPZ004777 order 0.02). Retention

did not differ between groups.

In line with a Multitude of preclinical studies examining the effects of baclofen on drug-motivated behavior, baclofen reduced CPD. In agreement with other studies examining craving and drug use, reductions in CPD were accompanied by a reduction in craving, a major motivator underlying continued smoking and relapse. These preliminary results demonstrate provisional evidence of the utility of baclofen to aid in smoking cessation and indicate further investigation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“Buprenorphine, a mu-opioid receptor partial agonist, has been shown to be safe and effective for treatment of opioid dependence. A novel implantable formulation of buprenorphine (Probuphine(R)), using a polymer matrix sustained-release technology, has been developed to offer treatment for opioid dependence while minimizing risks of patient noncompliance and illicit diversion. The goal of the current study was to conduct an initial, open-label, evaluation of the safety, pharmacokinetics, and efficacy of two doses of Probuphine in subjects with opioid dependence maintained on sublingual buprenorphine.

“
“The present work investigated on carotenogenesis with high beta-carotene content by a new isolated high-activity strain-producer Rhodotorula acheniorum mutant MRN in cheese whey

ultrafiltrate. After a serial of UV, ethymethanesurfonate (EMS), and nitrosoguanidine (NTG) mutagenesis, a mutant named MRN of the red lactose-positive yeast strain R. acheniorum was obtained. Then, the effects of different growth medium factors on carotenoid production by this mutant at batch-scale level were identified and optimized by means of response surface methodology (RSM) in order to achieve high-level production of beta-carotene. The optimum conditions required to achieve the highest level of beta-carotene (262.12 +/- 1.01 mg/L)

were determined as follows: whey ultrafiltrate (WU) lactose concentration 55 g/L, pH 5.85, ammonium sulfate concentration 3.5 g/L, temperature ITF2357 23A degrees C, and aeration rate 1.56 vvm. The medium optimization resulted in a 6.45-fold increase in volumetric production (262.12 +/- 1.01 mg/L) and a 4.62-fold increase in the cellular accumulation (10.69 +/- 0.19 mg/g) of beta-carotene.”
“Epitaxial Pb(Zr,Ti)O-3 (PZT) thick films of 2.0-3.0 mu m thickness were grown at 600 degrees C on (100)(c)SrRuO3 parallel to(100)SrTiO3 and (100)(c)SrRuO3 parallel to(100)LaNiO3 parallel to(100)CaF2 substrates by pulsed-metal organic chemical vapor deposition. All films showed (100) and/or (001) orientations with tetragonal symmetry. It was found that there is AZD8055 clinical trial an almost linear relationship between the estimated thermal strain from the deposition temperature to the Curie temperature and the volume fraction of (001) orientation in the mixture of (100) and (001) orientations for the films on check details both substrates. Consequently, the perfectly (001)-oriented, i.e., polar-axis-oriented, PZT thick films were obtained on CaF2 with the Zr/(Zr+Ti) ratio from 0.20 to 0.40. Moreover, the lattice parameter of a- and c-axes and their ratio (c/a) of those polar-axis-oriented films

were almost the same as the reported data for the powder, suggesting that the large strain is not remaining in those films. The relative dielectric constant (epsilon(r)) of the polar-axis-oriented Pb(Zr0.35Ti0.65)O-3 thick film on CaF2 was 180 at 1 kHz, which is lower than that of (100)/(001)-oriented thick films on SrTiO3 but almost agrees with the theoretically calculated value for the c-axis of PZT single crystals. Well saturated polarization-electric-field hysteresis loops with a good square shape were observed for the polar-axis-oriented thick films, and the saturation polarization and the coercive field values were 74 mu C/cm(2) and 64 kV/cm, respectively. These data clearly show that the electrical properties of the polar-axis-oriented epitaxial thick films are similar to the theoretical predictions for PZT single crystals.

Moreover, obvious hysteresis behavior is observed in the in-plane GMR curve of

the dual spin valve. This phenomenon results from the hindered rotation of the Co/Pd moments due to the magnetostatic coupling between the top and bottom Co/Pd multilayers in the dual spin valve. (C) 2010 American Institute of Physics. [doi:10.1063/1.3385314]“
“Background: Mitochondrial damage is associated with histologic myocardial fibrosis. Late gadolinium enhancement (LGE) on cardiac magnetic resonance AC220 mouse (CMR) can be used to identify focal fibrosis. We examined whether myocardial fibrosis on CMR and collagen volume fraction (CVF) from biopsies correlated with left ventricular (LV) and mitochondrial function in patients with nonischemic dilated cardiomyopathy (DCM).

Methods and Results: Fifty-nine DCM patients underwent CMR, cardiac catheterization, and endomyocardial Anlotinib mouse biopsy. Minimum first derivative of LV pressure (LVdP/dt(min)) was measured as an index of LV relaxation. Mitochondrial RNA expression was also analyzed. For quantitative analysis of myocardial fibrosis, percentage LGE (%LGE) and CVF were calculated. Patients were divided into 2 groups on the basis of the presence (LGE group; n = 27) or absence (non-LGE group; n = 32) of LGE. Mean CVF and absolute value of LVdP/dt(min), were significantly

higher and lower, respectively, in the LGE group than in the non-LGE group. Multivariate analysis revealed that %LGE was an independent determinant of LVdP/dt(min). The abundance of mitochondrial enzyme mRNA was significantly lower in the LGE group.

Conclusions: Noninvasive CMR imaging is more useful in predicting diastolic dysfunction than invasive histologic assessments. In addition, it might indicate mitochondrial dysfunction in https://www.sellecn.cn/products/LDE225(NVP-LDE225).html DCM.”
“BACKGROUND: Pulmonary injury leading to early allograft dysfunction is caused by ischemia-reperfusion injury (IR) and originates from multiple pathogenic events, including endothelial damage, neutrophil extravasation into tissue, and peroxidation

of cell membrane lipids, followed by pulmonary cell alterations and edema. The potent vasoconstrictor and proinflammatory mediator endothelin (ET)-1 plays a major role in this cascade. This study was conducted to determine whether treatment with relaxin, an anti-inflammatory and vasoactive hormone, prevents IR.

METHODS: Isolated male Wistar rat lungs were perfused in a recirculatory model in the presence of 5-nmol/liter relaxin (n = 17) or vehicle alone (n = 14). After IR (60 minutes each) we determined wet-to-dry weight ratio, and levels of ET-1, neutrophil elastase (NE), myeloperoxidase (MPO), and malondialdehyde (MDA).

RESULTS: IR lungs displayed significantly elevated W/D ratios after IR compared with control lungs = 0.001).

The majority (81%) of patients underwent surgery, either for valve replacement and debridement of a cardiac abscess, or removal of an infected EX 527 cost device. Crude in-hospital mortality was 16%. The median duration of postoperative antibiotic treatment was 42 days. Patients were commonly treated with a penicillin derivative alone or in combination with gentamicin. On the basis of the above data, it is recommended that infective endocarditis should be strongly suspected when Propionibacterium species are

isolated from multiple blood cultures, particularly in the presence of a cardiovascular device.”
“Study Design. Retrospective study.

Objective. To evaluate the prognostic value of preoperative pulmonary function test (PFT) for postoperative pulmonary complications

and to identify the operability associated with severely decreased forced vital capacity (FVC) (<30%) status in flaccid neuromuscular scoliosis.

Summary of Background Data. Selleck TPCA-1 The preoperative PFT, especially more than 30% FVC, is known as a critical factor for the operability of flaccid neuromuscular scoliosis. But only one study reported that patients with pre-existing respiratory failure on nocturnal noninvasive ventilation can undergo an operation for deformity correction without mortality and severe complications.

Methods. A total of 74 patients (45 male and 29 female) presented with flaccid neuromuscular scoliosis. For all patients, preoperative PFTs were evaluated and subdivided into three groups (< 30% FVC, 30%-50% FVC, and >50% FVC). Then postoperative pulmonary complications, pneumothorax, pneumonia, atelectasis, prolonged ventilator care in the intensive care unit (more than 72 hours), and postoperative tracheostomy were evaluated.

Results. Among these patients, 59 had muscular dystrophy; selleckchem 5, spinal muscular atrophy; 2, cerebral palsy; and 8, others. The mean age at surgery was 16.8 years (range, 5-32 years). The mean preoperative Cobb angle

was 54.6 degrees (16 degrees-135 degrees). The overall postoperative pulmonary complication rate was 31% (23 complications in 74 patients). The less than 30% FVC group had 6 complications among 18 patients; the 30% to 50% FVC group had 7 complications among 18 patients; and the more than 50% FVC group had 10 complications among 38 patients. There were no deaths during the perioperative period. There is no statistical difference between the three groups (P = 0.6195).

Conclusion. Patients with flaccid neuromuscular scoliosis can undergo an operation for deformity correction regardless of the severely decreased pulmonary function.”
“Plant retinoblastoma-related (RBR) proteins are primarily considered as key regulators of G(1)/S phase transition, with functional roles in a variety of cellular events during plant growth and organ development.

This resulted in different surface morphologies over the click here ENM surface. The best approach B allowed the separation of 80.7% of 2000-ppm MgSO4 and 67.0% of 2000-ppm NaCl at a pressure of 70 psig under a dead-end filtration setup. The fluxes attained were 0.51 and 0.52 L m-2 h-1, respectively. In addition, the effect of the pore size on the formation of a polyamide film was investigated. It was realized that bubble points of 1.8 and 3.4 mu m were both able to support the polymer film on its surface, but their separation efficiency differed slightly. These findings suggest that ENMs could be used beyond their current microfiltration stage, and hence, their use could be widened

to NF membranes. (C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Background: Individuals vary in their subjective and behavioral response to psychomotor www.selleckchem.com/products/tariquidar.html stimulants and these differences may be associated with the likelihood of developing problematic use of these drugs. The present study sought to determine whether individual differences in caffeine choice prospectively predict subjective response to acute doses of caffeine and d-amphetamine.

Methods: In Phase 1, Choosers and Nonchoosers of caffeine were identified using 10 independent choice trials in which subjects repeatedly chose between caffeine

(200 mg/70 kg) and placebo. Choosers were defined as those who chose caffeine over placebo on >= 7 of the 10 trials; Nonchoosers were those who chose placebo on >= 7 trials. In Phase 2, Choosers and Nonchoosers were compared in their subjective response to caffeine (100, 200, 400 mg/70 kg) and d-amphetamine (5, 10, 20 mg/70 kg).

Results: Of the 22 participants completing the study, 11 met criteria for being a caffeine Chooser and 8 were Nonchoosers. In Phase 1, Choosers reported higher ratings of positive (i.e., pleasant) and lower ratings of negative (i.e., unpleasant) effects of caffeine during the sampling sessions. In Phase 2, caffeine Choosers reported more positive subjective effects and fewer negative effects of caffeine and d-amphetamine, particularly at the highest

doses examined.

Conclusions: selleck compound Individual differences in caffeine reinforcement predicted subsequent subjective response to both d-amphetamine and caffeine. This observation may have clinical utility for identifying individuals who are vulnerable to the reinforcing effects of abused psychomotor stimulants. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Background: Equol and O-desmethylangolensin (ODMA) are products of gut bacterial metabolism of daidzein, a phytochemical found predominantly in soy. Dietary sources of equol from animal products have been identified, which has raised the question of the relative contributions of daidzein intake and gut metabolism to equol and of equol intake from animal products in low-soy-consuming populations.